587885-53-8

Basic information

• Product Name: Glycine, N-[1-oxo-2-(trifluoromethyl)-2-propenyl]-, phenylmethyl ester
• CAS NO: 587885-53-8
• Molecular Formula: C13H12F3NO3
• Molecular Weight: 287.238
• Mol File: 587885-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Glycine, N-[1-oxo-2-(trifluoromethyl)-2-propenyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[1-oxo-2-(trifluoromethyl)-2-propenyl]-, phenylmethyl ester(587885-53-8)
• EPA Substance Registry System: Glycine, N-[1-oxo-2-(trifluoromethyl)-2-propenyl]-, phenylmethyl ester(587885-53-8)

Safety Data

• Hazardous Substances Data: 587885-53-8(Hazardous Substances Data)

Upstream product

• 2462-31-9 benzyl 2-aminoacetate hydrochloride 
• 90715-73-4 2-(trifluoromethyl)acrylic chloride 

Relevant articles and documents

Highly stereoselective tandem aza-Michael addition-enolate protonation to form partially modified retropeptide mimetics incorporating a trifluoroalanine surrogate

Fine-tuning of key reaction parameters, such as the solvent and the base used, led to a dramatic improvement in d.r. (from ≈1:1 to 38:1) in a tandem aza-Michael addition-enolate protonation sequence. Thus, the reaction of α-amino ester nucleophiles 1 with N-(α-trifiuoromethyl)acryloyl-α-amino ester acceptors 2 produced an array of partially modified retropeptide mimetics 3 with good to excellent stereocontrol (R, R1, R2, X, X1 = alkyl).