588-09-0

Basic information

• Product Name: 2-Chloro-5-(trifluoroMethoxy)nitrobenzene
• Synonyms: 2-Chloro-5-(trifluoroMethoxy)nitrobenzene;1-Chloro-2-nitro-4-(trifluoromethoxy)benzene;4-Chloro-3-nitrophenyl trifluoromethyl ether;4-chloro-3-nitro-trifluoromethoxybenzene
• CAS NO: 588-09-0
• Molecular Formula: C₇H₃ClF₃NO₃
• Molecular Weight: 241.5518296
• Mol File: 588-09-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 247℃
• Flash Point: 103℃
• Appearance: /
• Density: 1.572
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-5-(trifluoroMethoxy)nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-(trifluoroMethoxy)nitrobenzene(588-09-0)
• EPA Substance Registry System: 2-Chloro-5-(trifluoroMethoxy)nitrobenzene(588-09-0)

Safety Data

• Hazardous Substances Data: 588-09-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-(trifluoroMethoxy)nitrobenzene is a chemical compound with the molecular formula C7H4ClF3NO3. It is a nitrobenzene derivative with a chlorine atom and a trifluoromethoxy group attached to the benzene ring. 2-Chloro-5-(trifluoroMethoxy)nitrobenzene is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and other organic compounds. It is also a versatile building block for the preparation of various functionalized aromatic compounds. 2-Chloro-5-(trifluoroMethoxy)nitrobenzene is a highly reactive and potentially hazardous compound that requires careful handling and storage.

InChI:InChI=1S/C7H3ClF3NO3/c8-5-2-1-4(15-7(9,10)11)3-6(5)12(13)14/h1-3H

Upstream product

• 461-81-4 1-chloro-4-(trifluoromethoxy)benzene 
• 1006904-72-8 silver(I) trifluoromethoxide 
• 635-22-3 4-Chloro-3-nitroaniline 

Downstream Products

• 1261791-19-8 4-chloro-2(-3)-nitrotrifluoro-methoxybenzene 

Relevant articles and documents

Co-production preparation method of o-amino trifluoromethoxy benzene and m-amino trifluoromethoxy benzene

The invention discloses a co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene, and belongs to the technical field of fine chemical engineering. Thepreparation method comprises the following steps: (1) nitration reaction: carrying out nitration reaction on 4-chlorine-trifluoromethoxybenzene to obtain a mixture of 4-chlorine-2-nitro- trifluoromethoxy benzene and 4-chlorine-3-nitro-trifluoromethoxybenzene; (2) reduction and dechlorination: carrying out reduction and dechlorination on the mixture of the 4-chloro-2-nitro-trifluoromethoxybenzene and the 4-chloro-3-nitro-trifluoromethoxybenzene to obtain o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene; and (3) rectification separation: separating the o-amino trifluoromethoxybenzene from the m-amino trifluoromethoxybenzene through rectification so as to realize co-production. The method is low in cost and high in yield, two useful chemical products are obtained at the same time, the process is simple, and industrial production is easy to achieve.

Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds.

LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT

Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.