58821-27-5

Basic information

• Product Name: Propanamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-
• CAS NO: 58821-27-5
• Molecular Formula: C11H15NO3S
• Molecular Weight: 241.311
• Mol File: 58821-27-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Propanamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-(58821-27-5)
• EPA Substance Registry System: Propanamide, 2-methyl-N-[(4-methylphenyl)sulfonyl]-(58821-27-5)

Safety Data

• Hazardous Substances Data: 58821-27-5(Hazardous Substances Data)

Upstream product

• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 127-65-1 chloroamine-T 
• 21849-40-1 dibromamine-T 
• 78-84-2 isobutyraldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 97-62-1 Ethyl isobutyrate 
• 67-64-1 acetone 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 941-55-9 4-toluenesulfonyl azide 
• 38383-77-6 methyl N-tosylisobutyrimidate 

Downstream Products

• 76227-58-2 dimethyl N-tosylketenimine 
• 86439-36-3 N-[1-Chloro-2-methyl-prop-(Z)-ylidene]-4-methyl-benzenesulfonamide 
• 78-82-0 Isobutyronitrile 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 76227-60-6 N-[3,3-Dimethyl-1,4-diphenyl-azetidin-(2E)-ylidene]-4-methyl-benzenesulfonamide 

Relevant articles and documents

Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides

The chemoselective cleavage of C-N bonds of amides, sulfonamides, and acylsulfonamides by aluminum halides is described. AlCl3and AlI3display complementary reactivities toward N-alkyl and N-acyl moieties. N-Alkylacylsulfonamides, sec

Iron(II)-catalyzed amidation of aldehydes with iminoiodinanes at room temperature and under microwave-assisted conditions

A method for the amidation of aldehydes with PhI=NTs/PhI=NNs as the nitrogen source and an inexpensive iron(II) chloride + pyridine as the in situ formed precatalyst under mild conditions at room temperature or microwave assisted conditions is described. The reaction was operationally straightforward and accomplished in moderate to excellent product yields (20-99%) and with complete chemoselectivity with the new C-N bond forming only at the formylic C-H bond in substrates containing other reactive functional groups. By utilizing microwave irradiation, comparable product yields and short reaction times of 1 h could be accomplished. The mechanism is suggested to involve insertion of a putative iron-nitrene/imido group to the formylic C-H bond of the substrate via a H-atom abstraction/radical rebound pathway mediated by the precatalyst [Fe(py)4Cl2] generated in situ from reaction of FeCl 2 with pyridine.

TiCl4-promoted direct N-acylation of sulfonamide with carboxylic ester

Several Lewis acids were investigated as promoters in the intermolecular or intramolecular direct N-acylation reaction of sulfonamides using carboxylic ester as an acylating agent. TiCl4 was found to possess the highest activity and enhanced efficiently sulfonamide to form N-acylsulfonamides under optimized conditions. This method provides a novel approach to make N-acylsulfonamides from ester via an easy work-up procedure.