58889-64-8

Basic information

• Product Name: D-TYROSINOL
• Synonyms: D-TYROSINOL;(R)-3-(4-HYDROXYPHENYL)-2-AMINO-1-PROPANOL;Tyrosinol,D-;BENZENEPROPANOL, .BETA.-AMINO-4-HYDROXY-, (.BETA.R)-;(R)-4-(2-amino-3-hydroxypropyl)phenol;REF DUPL: D-Tyrosinol;4-((2R)-2-Amino-3-hydroxypropyl)phenol;D-Tyrosinol (R)-4-(2-amino-3-hydroxypropyl)phenol
• CAS NO: 58889-64-8
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.21
• Product Categories: Amino alcohols
• Mol File: 58889-64-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 375.2 °C at 760 mmHg
• Flash Point: 180.7 °C
• Appearance: /
• Density: 1.205 g/cm³
• Vapor Pressure: 2.7E-06mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• CAS DataBase Reference: D-TYROSINOL(CAS DataBase Reference)
• NIST Chemistry Reference: D-TYROSINOL(58889-64-8)
• EPA Substance Registry System: D-TYROSINOL(58889-64-8)

Safety Data

• Hazardous Substances Data: 58889-64-8(Hazardous Substances Data)

Usage

General Description

D-Tyrosinol, also known as dehydro dehydrophenylalanine, is a chemical compound that belongs to the class of tyrosine derivatives. It is a chiral molecule that exists in two enantiomeric forms, with D-tyrosinol being the natural form found in various plant sources such as Lathyrus sativus and Lathyrus cicera. D-Tyrosinol has been investigated for its potential biological activities, including its antioxidant and anti-inflammatory properties. It has also been studied for its role in the biosynthesis of various natural products. Overall, D-tyrosinol is a bioactive compound with potential applications in the pharmaceutical and nutraceutical industries.

InChI:InChI=1/C9H13NO2/c10-8(6-11)5-7-1-3-9(12)4-2-7/h1-4,8,11-12H,5-6,10H2/t8-/m1/s1

Upstream product

• 3410-66-0 D-tyrosine methyl ester 
• 402832-84-2 isovaleryl-L-tyrosyl-L-valyl-D-tyrosinol 
• 402832-88-6 n-butyryl-L-tyrosyl-L-leucyl-D-tyrosynol 
• 83345-46-4 N-(tert-butyloxycarbonyl)-L-tyrosinol 
• 402832-91-1 [1-benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 402832-92-2 {(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid tert-butyl ester 
• 402830-01-7 isovaleryl-L-tyrosyl-L-valyl-DL-tyrosinal 
• 402832-95-5 {(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 402832-83-1 isovaleryl-L-tyrosyl-L-valyl-L-tyrosinol 
• 402832-86-4 n-butyryl-L-tyrosyl-L-leucyl-L-tyrosynol 
• 556-02-5 tyrosine 
• 3728-20-9 D-tyrosine methylester hydrochloride 

Downstream Products

• 885021-89-6 (Z)-18-Bromo-octadec-9-enoic acid [(R)-1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethyl]-amide 

Relevant articles and documents

Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros

NIMA-related kinase 1 (Nek1) has lately garnered attention for its widespread function in ciliogenesis, apoptosis, and the DNA-damage response. Despite its involvement in various diseases and its potential as a cancer drug target, no directed medicinal chemistry efforts toward inhibitors against this dark kinase are published. Here, we report the structure-guided design of a potent small-molecule Nek1 inhibitor, starting from a scaffold identified by kinase cross-screening analysis. Seven lead compounds were identified in silico and evaluated for their inhibitory activity. The top compound, 10f, was further profiled for efficacy, toxicity, and bioavailability in a zebrafish polycystic kidney disease model. Administration of 10f caused the expansion of fluorescence-labeled proximal convoluted tubules, supporting our hypothesis that Nek1-inhibition causes cystic kidneys in zebrafish embryos. Compound 10f displayed insignificant inhibition in 48 of 50 kinases in a selectivity test panel. The findings provide a powerful tool to further elucidate the function and pharmacology of this neglected kinase.

New 1,4-anthracene-9,10-dione derivatives as potential anticancer agents

The amino-substituted anthracene-9,10-dione (9,10-anthraquinone) derivatives represent one of the most important classes of potential anticancer agents. To better understand the basic rules governing DNA sequence specificity, we have recently synthesized a new class of d- and l- aminoacyl-anthraquinone derivatives. We have tested these new compounds as cytotoxic agents, and we have correlated their activity with the configuration of the chiral aminoacyl moiety. Molecular modeling studies have been performed to compare the test drugs in terms of steric overlapping. (C) 2000 Elsevier Science S.A.