58905-71-8

Basic information

• Product Name: N''-HYDROXYTHIOPHENE-3-CARBOXIMIDAMIDE
• Synonyms: Thiophene-3-carboxamidoxime;N'-Hydroxythiophene-3-carboximidamide, N-Hydroxythiophene-3-carboxamidine;3-ThiophenecarboxiMidaMide,N-hydroxy-
• CAS NO: 58905-71-8
• Molecular Formula: C₅H₆N₂OS
• Molecular Weight: 142.181
• Mol File: 58905-71-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 85 °C(Solv: benzene (71-43-2))
• Boiling Point: 258.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• PKA: 14.57±0.50(Predicted)
• CAS DataBase Reference: N''-HYDROXYTHIOPHENE-3-CARBOXIMIDAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N''-HYDROXYTHIOPHENE-3-CARBOXIMIDAMIDE(58905-71-8)
• EPA Substance Registry System: N''-HYDROXYTHIOPHENE-3-CARBOXIMIDAMIDE(58905-71-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 58905-71-8(Hazardous Substances Data)

Usage

Uses

N''-Hydroxythiophene-3-carboximidamide

Upstream product

• 1641-09-4 3-thiophenecarbonitrile 

Downstream Products

• 500025-30-9 3-(3-(thiophen-3-yl)-1,2,4-oxadiazol-5-yl)propanoic acid 
• 1622348-59-7 5-phenyl-3-(thiophen-3-yl)-4,5-dihydro-1,2,4-oxadiazole 

Relevant articles and documents

2-(1,2,4-Oxadiazol-5-yl)anilines Based on Amidoximes and Isatoic Anhydrides: Synthesis and Structure Features

Abstract: An efficient one-pot method was developed for the synthesis of 2-(1,2,4-oxadiazol-5-yl)anilines via the reaction of amidoximes with isatoic anhydrides in a NaOH–DMSO medium at ambient temperature. The method allows to obtain structurally diverse

Entry into (E)-3-(1,2,4-oxadiazol-5-yl)acrylic acids via a one-pot ring-opening/ring-closing/retro-Diels-Alder reaction sequence

A simple and convenient one-pot method is reported for the synthesis of (E)-3-(3-aryl(heteroaryl, alkyl)-1,2,4-oxadiazole-5-yl)acrylic acids utilizing readily accessible or commercially available substituted benzamidoximes and inexpensive exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride. The method is based on the reaction of amidoximes with the anhydride in a basic medium at RT followed by an acid-catalyzed retro-Diels-Alder reaction. The observed stereoselective heterocyclization/retro-Diels-Alder cascade process is suitable for the synthesis of a wide range of substituted (E)-1,2,4-oxadiazole-5-ylacrylic acids featuring electron donating and electron withdrawing groups on the aryl moiety, as well as heteroaryl or alkyl substituents at position 3 of the 1,2,4-oxadiazole ring (42–79%; 15 examples).

Nortopsentin alkaloid derivatives and preparation thereof, and application of nortopsentin alkaloid derivatives to prevention and treatment of diseases and insect pests

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