59005-99-1

Basic information

• Product Name: threo-(1R,2R)-1-(4-nitrophenyl)-2-(dichloroacetamido)-1,3-propanediol 3-butanoate
• CAS NO: 59005-99-1
• Molecular Weight: 393.224
• Mol File: 59005-99-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: threo-(1R,2R)-1-(4-nitrophenyl)-2-(dichloroacetamido)-1,3-propanediol 3-butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: threo-(1R,2R)-1-(4-nitrophenyl)-2-(dichloroacetamido)-1,3-propanediol 3-butanoate(59005-99-1)
• EPA Substance Registry System: threo-(1R,2R)-1-(4-nitrophenyl)-2-(dichloroacetamido)-1,3-propanediol 3-butanoate(59005-99-1)

Safety Data

• Hazardous Substances Data: 59005-99-1(Hazardous Substances Data)

Upstream product

• 371-27-7 2,2,2-trifluoroethylbutyrate 
• 56-75-7 chloramphenicol 
• 141-75-3 butyryl chloride 
• 123-20-6 vinyl n-butyrate 
• 623-42-7 butanoic acid methyl ester 

Relevant articles and documents

Chloramphenicol Derivatives with Antibacterial Activity Identified by Functional Metagenomics

A functional metagenomic approach identified novel and diverse soil-derived DNAs encoding inhibitors to methicillin-resistant Staphylococcus aureus (MRSA). A metagenomic DNA soil library containing 19 200 recombinant Escherichia coli BAC clones with 100 Kb average insert size was screened for antibiotic activity. Twenty-seven clones inhibited MRSA, seven of which were found by LC-MS to possess modified chloramphenicol (Cm) derivatives, including three new compounds whose structures were established as 1-acetyl-3-propanoylchloramphenicol, 1-acetyl-3-butanoylchloramphenicol, and 3-butanoyl-1-propanoylchloramphenicol. Cm was used as the selectable antibiotic for cloning, suggesting that heterologously expressed enzymes resulted in derivatization of Cm into new chemical entities with biological activity. An esterase was found to be responsible for the enzymatic regeneration of Cm, and the gene trfA responsible for plasmid copy induction was found to be responsible for inducing antibacterial activity in some clones. Six additional acylchloramphenicols were synthesized for structure and antibacterial activity relationship studies, with 1-p-nitrobenzoylchloramphenicol the most active against Mycobacterium intracellulare and Mycobacterium tuberculosis, with MICs of 12.5 and 50.0 μg/mL, respectively.

Synthesis of Ester Derivatives of Chloramphenicol by Lipase-Catalyzed Transesterification in Organic Solvents

Regioselective esterification of chloramphenicol (1) and its synthetic analogue thiamphenicol (2) has been achieved by the action of lipase in acetone and several methyl carboxylates.Aliphatic and aromatic esters of different sizes and natures have been introduced selectively on the primary hydroxyl group of these molecules by modification of the reaction conditions (e.g., temperature, solvent, and lipase source).