59039-17-7

Basic information

• Product Name: Piperazine, 1-methyl-4-(methylsulfonyl)- (9CI)
• Synonyms: Piperazine, 1-methyl-4-(methylsulfonyl)- (9CI);1-METHYL-4-(METHYLSULFONYL)PIPERAZINE
• CAS NO: 59039-17-7
• Molecular Formula: C₆H₁₄N₂O₂S
• Molecular Weight: 178.25256
• Product Categories: PIPERIDINE
• Mol File: 59039-17-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 98-99 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 265.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 6.07±0.42(Predicted)
• CAS DataBase Reference: Piperazine, 1-methyl-4-(methylsulfonyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-methyl-4-(methylsulfonyl)- (9CI)(59039-17-7)
• EPA Substance Registry System: Piperazine, 1-methyl-4-(methylsulfonyl)- (9CI)(59039-17-7)

Safety Data

• Hazardous Substances Data: 59039-17-7(Hazardous Substances Data)

Upstream product

• 54533-09-4 N,N-bis(2-chloroethyl)methanesulfonamide 
• 74-89-5 methylamine 
• 109-01-3 1-methyl-piperazine 
• 63186-59-4 10,11-dihydro-dibenzo[b,f]thiepine-3,11-diol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 110417-56-6 2-((4-methylpiperazin-1-yl)sulfonyl)-1-phenylethan-1-one 
• 130214-78-7 (4-fluorophenyl)-[4-methylpiperazin-1-ylsulphamoylmethyl]-ketone 
• 130179-07-6 1-(4-Chloro-phenyl)-2-(4-methyl-piperazine-1-sulfonyl)-ethanone 
• 130179-06-5 1-(2-Chloro-phenyl)-2-(4-methyl-piperazine-1-sulfonyl)-ethanone 
• 130179-11-2 1-(4-Methoxy-phenyl)-2-(4-methyl-piperazine-1-sulfonyl)-ethanone 
• 130179-10-1 1-(4-tert-Butyl-phenyl)-2-(4-methyl-piperazine-1-sulfonyl)-ethanone 
• 130179-08-7 1-(2,4-Dichloro-phenyl)-2-(4-methyl-piperazine-1-sulfonyl)-ethanone 
• 130179-12-3 1-(3,4-Dimethoxy-phenyl)-2-(4-methyl-piperazine-1-sulfonyl)-ethanone 
• 130179-13-4 2-(4-Methyl-piperazine-1-sulfonyl)-1-(4-nitro-phenyl)-ethanone 
• 130179-09-8 2-(4-Methyl-piperazine-1-sulfonyl)-1-(4-trifluoromethyl-phenyl)-ethanone 
• 130178-93-7 1-[2-(4-Fluoro-phenyl)-ethynesulfonyl]-4-methyl-piperazine 
• 130178-91-5 1-[2-(4-Chloro-phenyl)-ethynesulfonyl]-4-methyl-piperazine 
• 130214-76-5 1-[2-(4-Methoxy-phenyl)-ethynesulfonyl]-4-methyl-piperazine 
• 130178-90-4 1-[2-(2-Chloro-phenyl)-ethynesulfonyl]-4-methyl-piperazine 

Relevant articles and documents

3-SUBSTITUTED CARBONYL-NAPHTHO[2,3-B]FURANE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: Formule (i) wherein X is an oxygen atom and the like; Y is -CO-, -S02-and the like; R1 is an optionally- substituted C1-6 alkyl group, an optionally-substituted C1-6 alkylcarbonyl group and the like; R2 is an optionally- substituted C1-6 alkyl group, an optionally-substituted C1-6 alkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R3, R4, R5, and R6 are independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

CHEMICAL COMPOUNDS

Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described

Fluorinated analogues of the tricyclic neuroleptics; 7-fluoro and 7-trifluoromethyl derivative of 10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin

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