59084-09-2

Basic information

• Product Name: 4-(4-METHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
• Synonyms: Pyridine, 1,2,3,6-tetrahydro-4-(4-methylphenyl)-
• CAS NO: 59084-09-2
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.25
• Mol File: 59084-09-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 286.5°C at 760 mmHg
• Flash Point: 131.5°C
• Appearance: /
• Vapor Pressure: 0.00262mmHg at 25°C
• CAS DataBase Reference: 4-(4-METHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(59084-09-2)
• EPA Substance Registry System: 4-(4-METHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(59084-09-2)

Safety Data

• Hazardous Substances Data: 59084-09-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15N/c1-10-2-4-11(5-3-10)12-6-8-13-9-7-12/h2-6,13H,7-9H2,1H3/p+1

Upstream product

• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 106-38-7 para-bromotoluene 
• 41979-39-9 4-piperidone hydrochloride 
• 1260882-14-1 tert-butyl 4-hydroxy-4-(p-tolyl)piperidine-1-carboxylate 
• 138647-53-7 1-tert-butyloxycarbonyl-4-(4-methylphenyl)-1,2,3,6-tetrahydropyridine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 4423-10-3 4-(p-tolyl)pyridine 
• 91801-94-4 4-bromo-4-p-tolyl-piperidine; hydrobromide 
• 201608-73-3 2a-[4-{4-(4-methylphenyl)-1,2,3 6-tetrahydropyridyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one 
• 437998-64-6 2-[4-(4-p-tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide 
• 1553930-01-0 N-{2-[4-(4-methylphenyl)-1,2,3,6-tetrahydropyridin-1-yl]ethyl}phthalimide 

Relevant articles and documents

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.