59095-84-0

Basic information

• Product Name: L-Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester
• CAS NO: 59095-84-0
• Molecular Formula: C25H32N2O6
• Molecular Weight: 456.539
• Mol File: 59095-84-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester(59095-84-0)
• EPA Substance Registry System: L-Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester(59095-84-0)

Safety Data

• Hazardous Substances Data: 59095-84-0(Hazardous Substances Data)

Upstream product

• 27601-29-2 t-butyloxycarbonyl-O-benzyl-L-tyrosine hydroxysuccinimide ester 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 73183-34-3 bis(pinacol)diborane 
• 642073-54-9 N-Boc-3-iodo-Tyr(Bzl)-Ala-OMe 
• 911675-15-5 Z-(7-bromo)Trp-NHMe 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 

Downstream Products

• 65671-30-9 Boc-Tyr(Bzl)-D-Ala-OH 
• 1628630-17-0 C₁₉H₂₀N₂O₃ 
• 642073-54-9 N-Boc-3-iodo-Tyr(Bzl)-Ala-OMe 
• 642073-57-2 N-Boc-3-iodo-Tyr(Bn)-AIa-7-bromo-Trp-OMe 
• 700376-95-0 N-Boc-3-iodo-Tyr(Bn)-Ala-OH 
• 911675-67-7 N-Boc-Tyr(Bn)-Ala-Trp-OH 
• 911675-44-0 N-Boc-Tyr(Bn)-Ala-Trp-NHCH₂Ph 
• 911675-65-5 N-Boc-Tyr(Bn)-Ala-Trp-OCH₃ 
• 944059-34-1 N-(tert-butoxycarbonyl)-3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)]-Tyr(Bn)-Ala-OMe 

Relevant articles and documents

Synthesis and conformational characterization of diketopiperazines bearing a benzyl moiety

Diketopiperazines bearing a benzyl moiety with different para-substituents were synthesized and analyzed by 1HNMR spectroscopy. All of these diketopiperazines were found to adopt a folded conformation according to the upfield chemical shift of the cis-proton (cis to the benzyl moiety) due to a shielding effect in the 1HNMR spectra. An intramolecular CH-π interaction appears to be an important factor for the folded conformation due to the effects of para-substituents on the benzyl group.

COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY

The present invention relates to the use of compounds of the following general formula (I): wherein no is 0 or 1, and when no is 1, X = CH2 or X = NCH2C6H5; R1 is OH, or a OR10 group, or a group of formula NH-(CH2)n1-R11; R2 is H, or an alkyl group, or a group of formula (CH2)n2-(CO)n3-NR13R14; R3 is H, or an alkyl group; R4 is H, or Boc, or Z; R5 is H, or Boc, or Z ; R6 is a OR16 group; R7 and R8 are H, or a halogen atom, as modulators of the proteasome activity, in the frame of the preparation of a medicament useful for the prevention or treatment of diseases wherein the proteasome is involved, or the preparation of cosmetic compositions, or of phytosanitary compositions.