59117-27-0Relevant articles and documents
Carbonyl homologation via α-trimethylsilyl β-lactone rearrangements. A nonbasic alternative to the Wittig reaction
Black,Zhang,Huang,Smith,Yates
, p. 15 - 20 (2007/10/02)
Saturated and unsaturated aldehydes and ketones, when treated with trimethylsilylketene and BF3 for 16 hours, form β-lactones which spontaneously rearrange to α,β-unsaturated TMS esters; these hydrolyze during workup to form the corresponding carboxylic acids.
Acetic acid derivatives having pharmacological activity and compositions containing the same
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, (2008/06/13)
Acetic acid derivatives of the formula: STR1 and pharmaceutically acceptable alkali metal salts thereof, wherein R represents the radical STR2 in which R1 and R2, which may be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a methyl radical and n is an integer in the range of from 0 to 3 inclusive. They possess a competitive inhibitory activity with respect to γ-aminobutyric α-ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders whether resulting or not from cerebral ischemia.
