591227-12-2

Basic information

• Product Name: Imidazo[1,2-a]pyrimidin-7-amine, 2-phenyl-
• Synonyms: 2-phenyl-imidazo[1,2-a]pyrimidin-7-ylamine;Imidazo[1,2-a]pyrimidin-7-amine,2-phenyl
• CAS NO: 591227-12-2
• Molecular Formula: C12H10N4
• Molecular Weight: 210.238
• Mol File: 591227-12-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-a]pyrimidin-7-amine, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyrimidin-7-amine, 2-phenyl-(591227-12-2)
• EPA Substance Registry System: Imidazo[1,2-a]pyrimidin-7-amine, 2-phenyl-(591227-12-2)

Safety Data

• Hazardous Substances Data: 591227-12-2(Hazardous Substances Data)

Upstream product

• 156-81-0 2,4-diaminopyrimidine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1335298-77-5 4-Chloro-2,5-dimethyl-2H-pyrazole-3-carboxylic acid (2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide 
• 1335299-50-7 3-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-pyrazine-2-carboxylic acid 
• 1335299-31-4 1-methyl-5-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1335299-28-9 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide 
• 1335299-32-5 1-methyl-5-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid 
• 1335299-81-4 1-Methyl-4-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid 
• 1335299-03-0 3,6-Dimethyl-pyridine-2-carboxylic acid (2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide 
• 1335299-73-4 1-Ethyl-5-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1335299-96-1 2-methoxy-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)nicotinamide 
• 1335298-74-2 4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide 
• 1335299-52-9 3-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-(pyridine-2-[carboxylic acid methylester]-3-carbonyl)-carbamoyl]-pyridine-2-carboxylic acid methyl ester 
• 1335299-99-4 2-chloro-6-methyl-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)isonicotinamide 
• 1335299-16-5 5-Bromo-3-methyl-pyridine-2-carboxylic acid (2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide 
• 1335299-98-3 2-methyl-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)isonicotinamide 

Relevant articles and documents

Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography

Aggregates of tau and beta amyloid (Aβ) plaques constitute the histopathological hallmarks of Alzheimer's disease and are prominent targets for novel therapeutics as well as for biomarkers for diagnostic in vivo imaging. In recent years much attention has been devoted to the discovery and development of new PET tracers to image tau aggregates in the living human brain. Access to a selective PET tracer to image and quantify tau aggregates represents a unique tool to support the development of any novel therapeutic agent targeting pathological forms of tau. The objective of the study described herein was to identify such a novel radiotracer. As a result of this work, we discovered three novel PET tracers (2-(4-[11C]methoxyphenyl)imidazo[1,2-a]pyridin-7-amine 7 ([11C]RO6924963), N-[11C]methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine 8 ([11C]RO6931643), and [18F]2-(6-fluoropyridin-3-yl)pyrrolo[2,3-b:4,5-c′]dipyridine 9 ([18F]RO6958948)) with high affinity for tau neurofibrillary tangles, excellent selectivity against Aβ plaques, and appropriate pharmacokinetic and metabolic properties in mice and non-human primates.

N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS

The invention is concerned with novel imidazopyrimidine derivatives of formula (I) wherein R1, R2 and R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDEIOA and used as medicaments.