59175-48-3

Basic information

• Product Name: 1-(2H-tetrazol-5-yl)isoquinoline
• Synonyms: isoquinoline, 1-(1H-tetrazol-5-yl)-
• CAS NO: 59175-48-3
• Molecular Formula: C₁₀H₇N₅
• Molecular Weight: 197.1961
• Mol File: 59175-48-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 477°C at 760 mmHg
• Flash Point: 236.4°C
• Density: 1.408g/cm³
• Vapor Pressure: 2.9E-09mmHg at 25°C
• Refractive Index: 1.722
• CAS DataBase Reference: 1-(2H-tetrazol-5-yl)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2H-tetrazol-5-yl)isoquinoline(59175-48-3)
• EPA Substance Registry System: 1-(2H-tetrazol-5-yl)isoquinoline(59175-48-3)

Safety Data

• Hazardous Substances Data: 59175-48-3(Hazardous Substances Data)

Usage

Description

1-(2H-tetrazol-5-yl)isoquinoline is a chemical compound with the molecular formula C11H7N5, characterized by its heterocyclic structure that includes a tetrazole ring and an isoquinoline moiety. 1-(2H-tetrazol-5-yl)isoquinoline is notable for its potential pharmacological activities, which are attributed to the presence of the tetrazole ring and the known biological activities of isoquinoline derivatives.

Uses

Used in Pharmaceutical Industry:
1-(2H-tetrazol-5-yl)isoquinoline is used as a potential therapeutic agent for various medical conditions due to its unique structural features and the wide range of pharmacological activities associated with tetrazole rings and isoquinoline derivatives. Its potential applications include anticancer, antiviral, and antimalarial treatments.
Used in Medicinal Chemistry and Drug Discovery:
1-(2H-tetrazol-5-yl)isoquinoline serves as a promising candidate in the field of medicinal chemistry and drug discovery. Its structural composition and potential biological activities make it a valuable compound for further research and development, with the aim of identifying new therapeutic agents and treatments for various diseases.

Upstream product

• 1198-30-7 1-isoquinolinecarbonitrile 

Downstream Products

• 29005-25-2 1H-indene-2-carbonitrile 
• 29872-81-9 1H-indene-3-carbonitrile 
• 91-59-8 naphthalen-2-ylamine 
• 6141-94-2 2,2'-azonaphthalene 

Relevant articles and documents

Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells

A family of five neutral cyclometalated iridium(III) tetrazolato complexes and their methylated cationic analogues have been synthesised and characterised. The complexes are distinguished by variations of the substituents or degree of π conjugation on either the phenylpyridine or tetrazolato ligands. The photophysical properties of these species have been evaluated in organic and aqueous media, revealing predominantly a solvatochromic emission originating from mixed metal-to-ligand and ligand-to-ligand charge transfer excited states of triplet multiplicity. These emissions are characterised by typically long excited-state lifetimes (～hundreds of ns), and quantum yields around 5–10 % in aqueous media. Methylation of the complexes caused a systematic red-shift of the emission profiles. The behaviour and the effects of the different complexes were then examined in cells. The neutral species localised mostly in the endoplasmic reticulum and lipid droplets, whereas the majority of the cationic complexes localised in the mitochondria. The amount of complexes found within cells does not depend on lipophilicity, which potentially suggests diverse uptake mechanisms. Methylated analogues were found to be more cytotoxic compared to the neutral species, a behaviour that might to be linked to a combination of uptake and intracellular localisation.

Microwave Synthesis of 5-Substituted 1 H-Tetrazoles Catalyzed by Bismuth Chloride in Water

(Chemical Equation Presented). Bismuth chloride was used to catalyze the [2 + 3] cycloaddition between sodium azide with aryl nitriles, aliphatic nitriles, and vinyl nitriles. A number of 5-substituted 1H-tetrazoles were synthesized in water or isopropano