591755-12-3Relevant articles and documents
Synthesis and evaluation of new 4(3H)-Quinazolinone derivatives as potential anticancer agents
Gatadi, Srikanth,Pulivendala, Gauthami,Gour, Jitendra,Malasala, Satyaveni,Bujji, Sushmitha,Parupalli, Ramulu,Shaikh, Mujahid,Godugu, Chandraiah,Nanduri, Srinivas
, (2019/09/30)
A series of new 4(3H)-quinazolinones were synthesized and evaluated for their cytotoxic activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 and HT-29 (colon) and A549 (lung). Among the tested compounds, 22a exhibited p
Pd-catalyzed and copper assisted regioselective sequential C2 and C7 arylation of thiazolo[5,4-f]quinazolin-9(8H)-one with aryl halides
Harari, Marine,Couly, Florence,Fruit, Corinne,Besson, Thierry
supporting information, p. 3282 - 3285 (2016/07/13)
A selective functionalization of thiazolo[5,4-f]quinazolin-9(8H)-one has been developed through sequential activation of C-H bonds to furnish diarylated compounds. This strategy allows the regioselective C2 and C7 arylation by a judicious choice of coupling partners and bases, requiring no additional ligands or directing groups. Differently substituted N8-benzylated-2,7-diaryl-thiazoloquinazolin-9(8H)-ones were thereby obtained in a facile manner. A one-pot procedure was also performed. These protocols provide a synthetically useful route for late-stage functionalization of this highly valuable scaffold, required in drug discovery.
Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3
Testard, Alexandra,Loge, Cedric,Leger, Benoit,Robert, Jean-Michel,Lozach, Olivier,Blairvacq, Melina,Meijer, Laurent,Thiery, Valerie,Besson, Thierry
, p. 3419 - 3423 (2007/10/03)
In an effort to identify new protein kinase inhibitors with increased potency and selectivity, we have developed the microwave-assisted synthesis of thiazolo[5,4-f]quinazolin-9-ones. The effects of eighteen derivatives on CDK1/cyclin B, CDK5/p25, and GSK-
