5918-77-4

Basic information

• Product Name: 2-Pyridinamine, N-[(4-nitrophenyl)methylene]-
• CAS NO: 5918-77-4
• Molecular Formula: C12H9N3O2
• Molecular Weight: 227.222
• Mol File: 5918-77-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Pyridinamine, N-[(4-nitrophenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine, N-[(4-nitrophenyl)methylene]-(5918-77-4)
• EPA Substance Registry System: 2-Pyridinamine, N-[(4-nitrophenyl)methylene]-(5918-77-4)

Safety Data

• Hazardous Substances Data: 5918-77-4(Hazardous Substances Data)

Upstream product

• 23574-81-4 N-(triphenylphosphoranylidene)pyridin-2-amine 
• 555-16-8 4-nitrobenzaldehdye 
• 504-29-0 2-aminopyridine 

Downstream Products

• 13313-19-4 (4-nitro-benzylidene)-[3]pyridyl-amine 
• 897664-58-3 (E,E)-N,N'-bis(4-nitrobenzylidene)hexane-1,4-diamine 
• 65838-46-2 (1E,1'E)-N,N'-(ethane-1,2-diyl)bis(1-(4-nitrophenyl)methanimine) 
• 7498-40-0 4-nitro-N-pyridine-2-yl-benzamide 
• 555-16-8 4-nitrobenzaldehdye 
• 79202-14-5 diethyl phosphonate 
• 42178-54-1 N,N'-p-Nitrobenzyliden-bis(2-aminopyridin) 

Relevant articles and documents

Synthesis and molecular docking studies of imines as α-glucosidase and α-amylase inhibitors

Imine functionality is found in many compounds with important biological activity. Thus, the development of novel synthetic approaches for imines is important. In this work, it is propose an easy, eco-friendly and straightforward synthesis pathway of aryl imines under microwave irradiation catalyzed by Alumina-sulfuric acid. In addition, the in vitro enzymatic inhibition, antioxidant activity and molecular docking studies were performed. The aryl imines were isolated with yields in the range of 37–94%. All aryl imines synthesized were evaluated for in vitro inhibitory potential against α-glucosidase and α-amylase enzymes and the results exhibited that the most of the compounds displayed inhibitory activity against both enzymes. The (E)-1-(4-nitrophenyl)-N-(pyridin-2-yl)methanimine (3d) was 1.15-fold more active than acarbose against α-amylase whilst the (E)-1-phenyl-N-(pyridin-2-yl)methanimine (3c) displayed similar activity that acarbose against α-glucosidase. The molecular docking studies in α-glucosidase and α-amylase reveal that aryl imines mainly establish an H-bond with the R2-subtituent and hydrophobic interactions with the R1-subtituent. The docking analysis reveals these synthetic aryl imines 3d-i interact in same active site than acarbose drug in both enzymes.

INVERSE ELECTRON DEMAND DIELS-ALDER REACTION OF 2-(ARYLMETHYLENEAMINE)-PYRIDINES WITH ENAMINES AND STYRENES. SYNTHESIS OF PYRAMIDINE DERIVATIVES

The reaction of 2-(arylmethyleneamino)-pyridines bearing an electron withdrawing group on the arylmethylene moiety 1 a, b and 2 a, b as heterodienes, with enamines 3 a, b or styrenes 4 a, b as dienophiles, affords, the corresponding pyrimidines by means o

NEW SYNTHETIC METHODOLOGY FOR THE PREPARATION OF SUBSTITUTED 1-ARYL-1-PYRIDYLAMINOMETHANEPHOSPHONIC ACID ESTERS

Esters of 1-phenyl-1-pyridylaminomethanephosphonates generally cannot, or only in poor yields be prepared by the usual methods by treatment of the appropriate Schiff base with diethyl or diphenyl phosphite.However, it was found that these phosphonates are