59224-23-6

Basic information

• Product Name: methyl 2-(2-oxo-2H-indol-3-yl)hydrazinecarbodithioate
• Synonyms: hydrazinecarbodithioic acid, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-, methyl ester, (2Z)-; Methyl (2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinecarbodithioate
• CAS NO: 59224-23-6
• Molecular Formula: C₁₀H₉N₃OS₂
• Molecular Weight: 251.328
• Mol File: 59224-23-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 434°C at 760 mmHg
• Flash Point: 216.3°C
• Density: 1.47g/cm³
• Vapor Pressure: 9.8E-08mmHg at 25°C
• Refractive Index: 1.737
• CAS DataBase Reference: methyl 2-(2-oxo-2H-indol-3-yl)hydrazinecarbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2-oxo-2H-indol-3-yl)hydrazinecarbodithioate(59224-23-6)
• EPA Substance Registry System: methyl 2-(2-oxo-2H-indol-3-yl)hydrazinecarbodithioate(59224-23-6)

Safety Data

• Hazardous Substances Data: 59224-23-6(Hazardous Substances Data)

Upstream product

• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 1117816-15-5 3-(1,2-diaza-2-{5-[(5-chlorobenzo[d]furan-2-yl)carbonyl-3-phenyl]-(1,3,4-thiadiazolin-2-ylidene)}ethylidine)indolin-2-one 
• 1131275-18-7 C₂₅H₁₅N₅O₃S 

Relevant articles and documents

The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA)2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. Springer Science+Business Media, LLC 2011.

Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity

Six compounds were synthesized with piperazine in linker region and hydroxamate as Zinc Binding Group (ZBG). They were screened against three cancer cell-lines (NCIH460; HCT116; U251). Compounds 5c and 5f with GI50 value of 9.33 ± 1.3 μM and 12.03 ± 4 μM, respectively, were tested for their inhibitory potential on hHDAC8. Compound 5c had IC50 of 33.67 μM. Compounds were also screened for their anticancer activity against HL60 human promyelocytic leukemia cell line due to the presence of pharmacophoric features of RR inhibitors in them. Compound 5c had IC 50 of 0.6 μM at 48 h.