59227-89-3 Usage
Description
Laurocapram, also known as Glycerol monocaprylate, is a colorless or slightly yellow transparent liquid that is insoluble in water but can form an emulsion with it. It is soluble in various organic solvents and is a useful intermediate in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Laurocapram is used as a pharmaceutic aid (excipient) for its ability to act as an inert substance, ensuring the shelf-life of active ingredients is long enough for internal use.
Used in Cosmetic and Personal-Care Industry:
Laurocapram is used as a penetration enhancer in cosmetic preparations and personal-care products, improving the absorption of active ingredients into the skin.
Used in Pesticides:
Laurocapram is used as a pro-absorbing agent and sterilization plant growth regulator, enhancing the effectiveness of pesticides by improving their penetration into plants.
Used in Leather Industry:
Laurocapram can be used as an accelerator in the coloring and dyeing of leather, improving the efficiency and quality of the process.
Used as Antifungal Lipopeptide:
Laurocapram has applications in the development of antifungal agents, particularly in the form of lipopeptides, which can be effective against various fungal infections.
Penetration enhancer
Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.
Laurocapram on hydrophilic and lipophilic drugs have significantly transdermal Aided role.? It has good aided effect on many kinds of plant extracts in emulsion state or colloidal state, and alkaloids effect is particularly evident. Transdermal penetration is stronger than dimethyl sulfoxide. 8-bromo cyclic nucleotide containing 1% azone permeability effect is equivalent to 12 times the 50% dimethyl sulfoxide. Often in combination with propylene glycol, synergy, the best use of transdermal concentration of 0.1% to 5%, safe and low toxic, non-irritating. The chemical property is stable, and it is kept up to four years at the room temperature.
It can be considered a decyl methyl sulfoxide with pyrrolidone composite for good novel penetration enhancers, skin irritation. It can promote the drug through the skin barrier corticosteroids, indomethacin, fluorouracil, hydroquinone and many other drugs transdermal absorption, improving local and systemic blood concentration, and improving the bioavailability of the drug. Lipophilic, they have transdermal effect for hydrophilic drugs. It can soften the skin and enhance its permeability. They have anti-inflammatory, analgesic and anti-itching effect. Low toxicity, oral LD50> 7g/kg, it is not compatible with strong acids or Vaseline to avoid reduce the effect.
References
http://www.chemicalland21.com/lifescience/foco/LAUROCAPRAM.htm
Check Digit Verification of cas no
The CAS Registry Mumber 59227-89-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,2 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 59227-89:
(7*5)+(6*9)+(5*2)+(4*2)+(3*7)+(2*8)+(1*9)=153
153 % 10 = 3
So 59227-89-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-13-16-19-17-14-12-15-18(19)20/h2-17H2,1H3
59227-89-3Relevant articles and documents
Process for the preparation of N-substituted lactams
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, (2008/06/13)
The invention relates to a process for the preparation of N-substituted lactams by reaction of a lactam, which is unsubstituted on the nitrogen, with an organic halide in the presence of at least one solid-liquid phase transfer catalyst, such as a quaternary ammonium salt, and of at least one solid inorganic base, such as an alkali metal hydroxide, and in the absence of solvent. By this process, N-substituted lactams are obtained with good yields and high purity. The absence of solvent makes possible a considerable gain in productivity and an improvement in safety and in regard for the environment.
N-allyl-lactams as crystallization inhibitors
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, (2008/06/13)
Crystallization of active material in spraying of an aqueous solution of certain specified fungicides is retarded by incorporation therein of an N-alkyl-lactam of the formula STR1 in which R represents alkyl having 6 to 18 carbon atoms and n represents the numbers 3, 4 or 5.
Solid formulations
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, (2008/06/13)
New solid formulations of A) at least one agrochemical active compound, B) at least one additive from the groups mentioned in the description, C) at least one dispersant, D) at least one carrier and E) if appropriate, further active compounds and/or additives, a process for preparing the solid formulations and their use for treating plants. A new device for preparing new granules.