59238-66-3

Basic information

• Product Name: N-(4-TERT-BUTYL-PHENYL)-BENZAMIDE
• Synonyms: N-(4-TERT-BUTYL-PHENYL)-BENZAMIDE
• CAS NO: 59238-66-3
• Molecular Formula: C₁₇H₁₉NO
• Molecular Weight: 253.33886
• Mol File: 59238-66-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 305.1°C at 760 mmHg
• Flash Point: 185°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.000839mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: N-(4-TERT-BUTYL-PHENYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-TERT-BUTYL-PHENYL)-BENZAMIDE(59238-66-3)
• EPA Substance Registry System: N-(4-TERT-BUTYL-PHENYL)-BENZAMIDE(59238-66-3)

Safety Data

• Hazardous Substances Data: 59238-66-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H19NO/c1-17(2,3)14-9-11-15(12-10-14)18-16(19)13-7-5-4-6-8-13/h4-12H,1-3H3,(H,18,19)

Upstream product

• 769-92-6 4-tert-Butylaniline 
• 98-88-4 benzoyl chloride 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 55-21-0 benzamide 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 154318-75-9 4-tert-butylphenyl triflate 
• 65-85-0 benzoic acid 
• 59970-38-6 4-tert-butylphenyl mesylate 
• 611-73-4 Benzoylformic acid 
• 253185-03-4 tert-butylbenzene 
• 100-47-0 benzonitrile 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 13463-40-6 iron pentacarbonyl 
• 591-50-4 iodobenzene 

Downstream Products

• 59238-54-9 N-(4-tert-Butyl-phenyl)-benzimidic acid ethyl ester 
• 59238-70-9 5-tert-Butyl-2-[N-(4-tert-butyl-phenyl)-benzimidoyloxy]-benzoic acid methyl ester 
• 59238-72-1 2-[N-(4-tert-Butyl-phenyl)-benzimidoyloxy]-benzoic acid methyl ester 
• 59238-35-6 2-Carboxy-4,4'-di-t-butyldiphenylamin 
• 59238-55-0 2-[Benzoyl-(4-tert-butyl-phenyl)-amino]-benzoic acid methyl ester 
• 59238-73-2 2-[Benzoyl-(4-tert-butyl-phenyl)-amino]-5-tert-butyl-benzoic acid methyl ester 
• 366-75-6 N-(4-fluorophenyl)benzamide 

Relevant articles and documents

Iron-catalyzed cross-coupling of N?methoxy amides and arylboronic acids for the synthesis of N-aryl amides

An efficient iron-catalyzed synthesis of N-aryl amides from N?methoxy amides and arylboronic acids is developed. FeCl3 is used as the sole catalyst for the cross-coupling reaction between N?methoxy amides and arylboronic acids without any other

Chromium-catalyzed ligand-free amidation of esters with anilines

Amides are important structural motifs in pharmaceutical and agrochemical chemistry because of the intriguing biological active properties. We report here the amidation of commercially available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution.

Amide Synthesis from Thiocarboxylic Acids and Amines by Spontaneous Reaction and Electrosynthesis

Amide bond formation is one of the most important basic reactions in chemistry. A catalyst-free approach for constructing amide bonds from thiocarboxylic acids and amines was developed. The mechanistic studies showed that the disulfide was the key intermediate for this amide synthesis. Thiobenzoic acids could be automatically oxidized to disulfides in air, thioaliphatic acids could be electro-oxidized to disulfides, and the resulting disulfides reacted with amines to give the corresponding amides. By this method, various amides could be easily synthesized in excellent yields without using any catalyst or activator. The successful synthesis of bioactive compounds also highlights the synthetic utility of this strategy in medicinal chemistry.