59247-13-1 Usage
Description
TRISIALOGANGLIOSIDE GT1B 3NA, also known as Ganglioside GT1b, is a glycosphingolipid that is composed of a neutral tetra-saccharide core with one or two sialic acid on the internal galactose and an extra sialic acid on the non-reducing terminal of galactose. It is anchored at the outer surface of the plasma membrane where it forms lipid microdomains with cholesterol, modulating both intraand inter-cellular signaling events. TRISIALOGANGLIOSIDE GT1B 3NA is characterized by having two sialic residues linked to the inner galactose unit and is available as a lyophilized powder.
Uses
Used in Immune Modulation:
TRISIALOGANGLIOSIDE GT1B 3NA is used as an immune modulator for its inhibitory effects on human humoral immune responses. At concentrations of 0.1-10 μM, it can inhibit spontaneous IgG, IgM, and IgA production by human peripheral blood mononuclear cells.
Used in Neuroprotection:
TRISIALOGANGLIOSIDE GT1B 3NA is used as a glycosphingolipid neuroprotectant in the pharmaceutical industry. It has been shown to provide neuroprotective effects and is used in the treatment of various neurological disorders.
Used in Viral Infection Research:
TRISIALOGANGLIOSIDE GT1B 3NA is used as a host cell receptor for the Merkel cell polyomavirus in the field of virology. It has been proposed as a means to enable the initiation of an infection leading to Merkel cell carcinoma, providing valuable insights into the virus-host interactions and potential therapeutic targets.
Used in Pharmaceutical Formulation:
TRISIALOGANGLIOSIDE GT1B 3NA is used as an active pharmaceutical ingredient in the development of drugs targeting immune modulation and neuroprotection. Its unique properties and ability to modulate cellular signaling make it a promising candidate for the development of novel therapeutics in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 59247-13-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,4 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 59247-13:
(7*5)+(6*9)+(5*2)+(4*4)+(3*7)+(2*1)+(1*3)=141
141 % 10 = 1
So 59247-13-1 is a valid CAS Registry Number.
InChI:InChI=1/C88H157N5O44/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-56(107)92-37-51(45(101)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)124-80-66(113)65(112)70(54(42-98)127-80)129-82-69(116)77(136-87(84(120)121)35-46(102)57(89)72(132-87)61(108)49(105)38-94)71(55(43-99)128-82)130-79-60(93-44(3)100)75(63(110)52(40-96)125-79)131-81-68(115)76(64(111)53(41-97)126-81)135-86(83(118)119)34-47(103)59(91)74(134-86)67(114)78(117)137-88(85(122)123)36-48(104)58(90)73(133-88)62(109)50(106)39-95/h30,32,45-55,57-82,94-99,101-106,108-117H,4-29,31,33-43,89-91H2,1-3H3,(H,92,107)(H,93,100)(H,118,119)(H,120,121)(H,122,123)/b32-30+/t45?,46-,47-,48-,49?,50?,51?,52-,53-,54+,55-,57+,58+,59+,60-,61?,62?,63+,64+,65+,66+,67?,68-,69-,70+,71+,72+,73+,74+,75-,76+,77-,78?,79+,80+,81+,82+,86+,87+,88+/m0/s1
