59255-94-6

Basic information

• Product Name: 2-Bromo-3-fluoronitrobenzene
• Synonyms: 2-BROMO-3-FLUORONITROBENZENE;2-Bromo-1-fluoro-3-nitrobenzene;2-broMo-3-fluorobroMobezene;Benzene, 2-bromo-1-fluoro-3-nitro-
• CAS NO: 59255-94-6
• Molecular Formula: C₆H₃BrFNO₂
• Molecular Weight: 220
• EINECS: 1533716-785-6
• Product Categories: blocks;Bromides;FluoroCompounds;NitroCompounds
• Mol File: 59255-94-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 42.0-44.0 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 222.326 °C at 760 mmHg
• Flash Point: 88.26 °C
• Appearance: /
• Density: 1.808 g/cm³
• Vapor Pressure: 0.152mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-3-fluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-fluoronitrobenzene(59255-94-6)
• EPA Substance Registry System: 2-Bromo-3-fluoronitrobenzene(59255-94-6)

Safety Data

• Hazard Codes: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 59255-94-6(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-fluoronitrobenzene is a specialized, multifunctional aromatic compound with a molecular formula of C6H3BrFNO2, principally used in the field of organic synthesis. This colorless to pale yellow liquid belongs to the class of organic compounds known as nitrobenzenes, characterized by a benzene ring with a nitro group attached to it. It contains atoms of bromine and fluorine, and the presence of a nitro group in its molecular structure can facilitate certain chemical reactions. As a reagent, it's principally involved in the syntheses of various organic products, and it may serve as a block builder in the pharmaceutical industry. Despite its utility in controlled laboratory environments, direct exposure can be harmful, necessitating appropriate safety measures during handling and storage.

InChI:InChI=1/C6H3BrFNO2/c7-6-4(8)2-1-3-5(6)9(10)11/h1-3H

Upstream product

• 17809-36-8 2-fluoro-6-nitroaniline 
• 399-31-5 N-(2-fluorophenyl)acetamide 
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• 402-67-5 3-fluoro-1-nitrobenzene 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 21397-08-0 2-chloro-3-fluoroaniline 
• 111721-75-6 2-bromo-3-fluoroaniline 
• 1000339-62-7 7-bromo-6-fluoro-1H-indole 
• 952664-87-8 N-(2-bromo-3-fluorophenyl)butyramide 
• 952664-88-9 N-(2-(3,3-dimethylbut-1-ynyl)-3-fluorophenyl)butyramide 
• 952664-89-0 2-tert-butyl-4-fluoro-1H-indole 
• 952664-90-3 2-tert-butyl-4-fluoro-5-nitro-1H-indole 
• 1338482-91-9 N-cyclopropyl-2-fluoro-6-nitroaniline 
• 1338482-92-0 N¹-cyclopropyl-6-fluorobenzene-1,2-diamine 
• 1338482-93-1 (S)-tert-butyl 1-(2-(cyclopropylamino)-3-fluorophenylamino)-1-oxopropan-2-ylcarbamate 
• 1384984-18-2 (+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea 
• 1384984-25-1 4-bromo-3-fluoro-2-(tetrahydrofuran-2-yl)aniline 
• 1384984-26-2 N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide 
• 1384984-27-3 4-bromo-3-fluoro-6-nitro-2-(tetrahydrofuran-2-yl)aniline 

Relevant articles and documents

Preparation method of 2 -bromo -3 -fluoronitrobenzene

The preparation method of 2 -bromo -3 -fluoronitrobenzene comprises the following steps: (1) reacting m-nitroaniline with bromosuccinimide to generate a compound III. (2) Compound III reacts with sodium nitrite and fluoroboric acid to generate compound IV

Preparation method of 1-fluoro-2-bromo-iodobenzene

The invention provides a preparation method of 1-fluoro-2-bromo-iodobenzene. The method comprises the steps that 1-fluorine-2-amidogen-3-nitrobenzene is used as a raw material, 1-fluorine-2-bromine-3-nitrobenzene is obtained through a diazotization and bromination reaction, 1-fluoro-2-bromo-aminobenzene is obtained through a following reduction reaction, and then 1-fluoro-2-bromo-iodobenzene is obtained through a diazotization and iodination reaction. According to the preparation method, under the acidic condition, 1-fluoro-2-bromo-aminobenzene and sodium nitrite react in a solvent, hydrogen iodide or iodate is added to the mixed solution, and 1-fluoro-2-bromo-iodobenzene is obtained through a reaction. The preparation method of 1-fluoro-2-bromo-iodobenzene is high in safety, mild in reaction condition, low in cost, easy to operate and industrialize and high in utilization rate of iodine.

A simple base-mediated halogenation of acidic sp2 C-H bonds under noncryogenic conditions

(Chemical Equation Presented) A new method has been developed for in situ halogenation of acidic sp2 carbon-hydrogen bonds in heterocycles and electron-deficient arenes. Either selective monohalogenation or one-step exhaustive polyhalogenation is possible for substrates possessing several C-H bonds that are flanked by electron-withdrawing groups. For the most acidic arenes, such as pentafluorobenzene, K3PO4 base can be employed instead of BuLi for metalation/halogenation sequences.