59363-12-1Relevant articles and documents
Male oral contraceptive N-alkylimidazole derivatives, compositions, and method of use therefor
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, (2008/06/13)
A compound useful as antifungal, antibacterial and antiprotozoal agents and as spermicides have the formula STR1 and the acid addition salts thereof wherein Z is oxygen or sulfur; m is 0, 1, 2 or 3; n is 1, 2 or 3; R1 is hydrogen; alkyl; cycloalkyl; cycloalkyl-lower-alkyl; optionally substituted phenyl; phenyl-lower-alkyl; monocyclic heteroaromatic ring; monocyclic heteroaromatic-lower-alkyl; naphthyl; or naphthyl-lower-alkyl. A and B are independently hydrogen, halo, lower alkyl or lower alkoxy and either one of A or B may be nitro, amino or alkanoylamino; Q is (a) NR2 R3 or (b) NR4 C(X)YR5 wherein X is oxygen or sulfur; Y is oxygen, sulfur, NR6 or a bond; R2 is hydrogen; alkyl; cycloalkyl; cycloalkyl-lower-alkyl; optionally substituted phenyl or optionally substituted phenyl-lower-alkyl; R3 is hydrogen or lower alkyl; or R2 and R3 together with N is a five or six membered optionally substituted ring; R4 and R6 are independently hydrogen or lower alkyl; R5 is lower alkyl; cycloalkyl; phenyl; or optionally substituted phenyl or phenyl-lower-alkyl.
Derivatives of thienyl- and furyl-substituted N-butyl and N-phenyl imidazoles
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, (2008/06/13)
The compounds of the present invention are represented by the formula STR1 wherein R1 and R2 are the same or different and are optionally substituted furyl or thienyl the substituents independently selected from the group halo, C1 to C6 alkyl and C1 to C6 alkoxy or optionally substituted phenyl the substituents independently selected from the group halo, C1 to C4 alkyl, C1 to C4 alkoxy and trifluoromethyl; X is oxygen or sulfur; m is the integer 0; and n is the integer 2 or 3; and the antimicrobial acid addition salts thereof, with the proviso that when either R1 or R2 is said optionally substituted phenyl the other R1 or R2 is said optionally substituted furyl or thienyl. The compounds are useful for combatting fungi, bacteria and protozoa. They also have spermatocidal and spermatostatic activity.