59394-96-6

Basic information

• Product Name: 2-benzylidene-1-(4-nitrobenzoyl)hydrazine
• CAS NO: 59394-96-6
• Molecular Weight: 269.26
• Mol File: 59394-96-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-benzylidene-1-(4-nitrobenzoyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzylidene-1-(4-nitrobenzoyl)hydrazine(59394-96-6)
• EPA Substance Registry System: 2-benzylidene-1-(4-nitrobenzoyl)hydrazine(59394-96-6)

Safety Data

• Hazardous Substances Data: 59394-96-6(Hazardous Substances Data)

Upstream product

• 62-23-7 4-nitro-benzoic acid 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 

Downstream Products

• 1366284-58-3 N-(2,2-difluoro-3-oxo-1,3-diphenylpropyl)-4-nitrobenzohydrazide 
• 32252-84-9 1-chloro-1-(4-nitrophenyl)-4-phenyl-2,3-diazabutadiene 
• 1090-82-0 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Antimicrobial Activity of N-(3-Chloro-2-aryl-4-oxoazetidin-1-yl)-4-nitro benzamide Derivatives

A series of N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-4-nitro benzamide derivatives (4a-g) were synthesized by reacting various N’-arylidene-4-nitro benzo hydrazide (3a-g) with chloro acetyl chloride in the presence of triethylamine and dioxane. Infrared (IR), proton nuclear magnetic resonance (1HNMR), and mass (MS) spectrometric techniques were used to describe the structure of synthesized compounds, which were further tested for in vitro antibacterial activity, and benzylpenicillin was used as a reference drug. Compounds (4b) and (4e) were showed high antibacterial action, whereas the remaining compounds (4a, 4c, 4d, 4f, and 4g) were showed moderate activity. Finally, this research demonstrates the design and development of novel antibacterial agents.

Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein

HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC50 values of 0.21 and 0.17 μΜ, respectively.

Synthesis of some novel pharmacologically active schiff bases using microwave method and their derivatives formazans by conventional method

Condensation of p-nitrobenzoylhydrazide 1 with substituted aromatic aldehydes 2 under microwave irradiation and by conventional method provide Schiff bases 3a-j. Schiff bases 3a-j on condensation with diazonium salt of 6-methoxy-2-aminobenzothiazole give formazans 4a-j. This reaction is carried out only by conventional method.