59397-23-8

Basic information

• Product Name: 1-phenylcycloheptanamine
• Synonyms: cycloheptanamine, 1-phenyl-
• CAS NO: 59397-23-8
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.2967
• Mol File: 59397-23-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 292.2°C at 760 mmHg
• Flash Point: 132.9°C
• Density: 0.973g/cm³
• Vapor Pressure: 0.00186mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: 1-phenylcycloheptanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylcycloheptanamine(59397-23-8)
• EPA Substance Registry System: 1-phenylcycloheptanamine(59397-23-8)

Safety Data

• Hazardous Substances Data: 59397-23-8(Hazardous Substances Data)

Usage

General Description

1-Phenylcycloheptanamine, also known as norcamphylamine, is a chemical compound with the formula C13H17N. It is a cyclic amine with a seven-membered ring and a phenyl group attached to the carbon. 1-phenylcycloheptanamine is used in the synthesis of various pharmaceuticals and as a precursor in the manufacturing of other organic compounds. 1-Phenylcycloheptanamine has been studied for its potential biological and psychological effects, including its role in the central nervous system as a stimulant and its potential as a designer drug. Additionally, it has been investigated for its potential use in treating Parkinson's disease and other neurodegenerative disorders. However, its use and effects on the human body are not fully understood, and it is important to handle this compound with caution and under the guidance of a qualified professional.

Upstream product

• 2082-21-5 1-phenylcycloheptanol 
• 502-42-1 cycloheptanone 
• 65542-30-5 7-Brom-1-phenyl-1-heptancarbonitril 
• 140-29-4 phenylacetonitrile 
• 108-86-1 bromobenzene 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 59358-72-4 1,1'-Diphenyl-1,1'-bicycloheptyl 
• 231961-56-1 1-(1-phenylcycloheptyl)piperidin-4-one 
• 79798-00-8 1-(1-phenylcycloheptyl)piperidine hydrochloride 
• 13683-43-7 N-cycloheptylidenebenzenamine 

Relevant articles and documents

Azetidine derivatives and synthesis method thereof

The invention belongs to the field of chemical synthesis, and discloses an azetidine derivative and a synthesis method thereof. The structural formula of the target product azetidine derivatives is asshown in formulae (I), (II), (III), (IV) and (V). The compounds of the formulae are compounds containing an azetidine skeleton, and a nitrogen atom in the skeleton is protected by 2-picolinic acid. The target product azetidine derivatives can be: azetidinyl amide derivatives, azabicyclo[x.1.1] amide derivatives (x=3, 4, 5, 6, 7, 8, 9), azabicyclo[4.1.1] amide derivatives having a substituent at the ring, azabicyclo[4.2.0] amide derivatives and azetidine derivatives containing spirocyclic quaternary carbon. The azetidine derivatives of the present invention have certain protective effect on hydrogen peroxide-induced oxidative stress damage of HC cells.

Syntheses and N-methyl-D-aspartate receptor antagonist pharmacology of fluorinated arylcycloheptylamines

Selective uncompetitive antagonists of the phencyclidine (PCP) binding site of the N-methyl-D-aspartate receptor (NMDAR) are known to have therapeutic potential as anticonvulsants and neuroprotective agents. Several fluorinated molecules with each containing a cycloheptane ring were designed to probe the PCP pharmacophore and test the influence of fluorine substitution on NMDAR binding and in vivo efficacy. Syntheses and analyses of six novel compounds, 1-(4-fluorophenyl)cycloheptanamine (3), 1-(1-(4-fluorophenyl)cycloheptyl)piperidine (4), 1-(1-(4-fluorophenyl)cycloheptyl) pyrrolidine (5), 1-(3-fluorophenyl)cycloheptanamine (6), 1-(1-(3-fluorophenyl)cycloheptyl)piperidine (7), 1-(1-(3-fluorophenyl)cycloheptyl)pyrrolidine (8) and several related reference arylcyloalkylamines are described. Receptor binding was performed at the PCP site of NMDAR for each compound using [3H]-(+)-MK-801 displacement. Unexpectedly, the 3-fluoro-primary amine 6 had the greatest affinity of the series and these binding results support a different structure activity relationship (SAR) profile for arylcycloheptylamines when compared to arylcyclohexylamines like PCP. Five of the novel compounds have affinity (Ki) in the hundred nM (10-7) range. In addition, compounds 3, 5, 6, 7 and 8 were evaluated and found to exhibit neuroprotective effects from NMDA induced toxicity in vitro and compounds 6, 7 and 8 exhibited anticonvulsant activities in rats. An ED50 of 13.84 mg/kg was found for compound 6 in rat maximal electroshock (MES) test with a protective index (PI) of 3.66 against ataxia. These results support further investigation of the arylcycloheptylamine class.

2-Phenyl-2-adamantanamine hydrochloride

-