59467-68-4

Basic information

• Product Name: Acetamide, N-[[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl] methyl]-
• CAS NO: 59467-68-4
• Molecular Formula: C18H17ClFN3O
• Molecular Weight: 345.804
• Mol File: 59467-68-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl] methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl] methyl]-(59467-68-4)
• EPA Substance Registry System: Acetamide, N-[[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl] methyl]-(59467-68-4)

Safety Data

• Hazardous Substances Data: 59467-68-4(Hazardous Substances Data)

Upstream product

• 59467-64-0 (7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine 

Relevant articles and documents

Convergent syntheses of carbon-13 labeled midazolam and 1′-hydroxymidazolam

For the purpose of drug interaction studies, the stable-isotope labeled [13C3]midazolam and its metabolite, 1′-hydroxy- [13C3]midazolam were synthesized in four and five steps in overall yields of 25.5% and 14.2%, from 7-chloro-5-(2-fluorophenyl)-2-(N- nitrosomethylamino)-3H-1,4-benzodiazepine, respectively, by a convergent synthesis, in which a key imidazoline ring formation was achieved by the facile reaction of [13C]2-aminomethyl-7-chloro-2,3-dihydro-5-(2- fluorophenyl)-1H-1,4-benzodiazepine with varying ethyl imidate hydrochlorides. The scrambling of C-3 and C-4 labeling in intermediate diamine, and consequently in the final products, as well as the formation of a Δ4,5 isomer of 1′-hydroxy-[13C3]midazolam was observed and explained.