59480-88-5

Basic information

• Product Name: (3,5-dimethylphenyl)(piperidin-1-yl)methanone
• CAS NO: 59480-88-5
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 217.3068
• Mol File: 59480-88-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 377.7°C at 760 mmHg
• Flash Point: 174.3°C
• Density: 1.049g/cm³
• Vapor Pressure: 6.64E-06mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: (3,5-dimethylphenyl)(piperidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-dimethylphenyl)(piperidin-1-yl)methanone(59480-88-5)
• EPA Substance Registry System: (3,5-dimethylphenyl)(piperidin-1-yl)methanone(59480-88-5)

Safety Data

• Hazardous Substances Data: 59480-88-5(Hazardous Substances Data)

Usage

Description

(3,5-dimethylphenyl)(piperidin-1-yl)methanone, also known as 3,5-dimethyl-α-piperidinophenylacetone, is a ketone derivative with a molecular formula of C15H21NO. It features a piperidine ring and a phenyl group, making it a potential precursor for the synthesis of various pharmaceutical and illicit drugs. Its structure also suggests potential central nervous system activity, which is of interest in medical and pharmacological research.
Used in Pharmaceutical Industry:
(3,5-dimethylphenyl)(piperidin-1-yl)methanone is used as a chemical intermediate for the synthesis of various pharmaceutical drugs due to its unique structure and potential central nervous system activity.
Used in Illicit Drug Production:
(3,5-dimethylphenyl)(piperidin-1-yl)methanone is used as a precursor in clandestine laboratories for the production of substances such as methamphetamine and MDMA, due to its ability to be converted into these drugs through chemical reactions.
Used in Medical and Pharmacological Research:
(3,5-dimethylphenyl)(piperidin-1-yl)methanone is used as a subject of interest in medical and pharmacological research for its potential central nervous system activity and its potential use in the development of new drugs.
Note: Due to its potential for abuse and classification as a controlled substance precursor, the sale, use, and possession of (3,5-dimethylphenyl)(piperidin-1-yl)methanone are heavily regulated in many jurisdictions.

Upstream product

• 110-89-4 piperidine 
• 499-06-9 3,5-dimethylbenzoic acid 
• 201230-82-2 carbon monoxide 
• 172975-69-8 3,5-dimethylphenyl boronic acid 
• 2156-71-0 N-chloropiperidine 
• 1013-92-9 di(piperidin-1-yl)methanethione 

Downstream Products

• 1527480-00-7 (2-iodo-3,5-dimethylphenyl)(piperidin-1-yl)methanone 

Relevant articles and documents

Palladium-Catalyzed Desulfurative Amide Formation from Thioureas and Arylboronic Acids

The development of the reactivity on carbene complexes would lead to the creation of novel synthetic strategies. We discovered herein the Pd-catalyzed desulfurative amide formation involved Suzuki-Miyaura coupling reaction, notably the Pd complex was generated in situ from thioureas, Ag salt and Pd catalyst. Silver salt was essential for the construction of this type of carbenes from available and stable thioureas and well participated in the catalytic cycle. We report a method for the synthesis of arylamides from arylboronic acids, which greatly enriched the application of thiourea chemistry and expanded the application of the Suzuki-Miyaura coupling.

Palladium-catalyzed aminocarbonylation of N-chloroamines with boronic acids

Abstract Aryl (pseudo)halide-based (C-X) carbonylation reactions have been extensively studied during the past few decades. From both academic and synthetic points of view, the carbonylative transformation of N-X bonds represents an interesting and attractive area of investigation. In light of this, the first carbonylative cross-coupling between N-chloroamines and organoboronic acids has been developed. This new type of aminocarbonylation proceeds at mild temperatures (45-55 °C) with 2 mol % Pd/C (10 wt %) as the ligand-free catalyst. Not only arylboronic acids, but also alkenyl- and alkylboronic acids can be applied as the substrates and bromide and iodide substituents in the substrates are well tolerated. Initial mechanistic investigations have also been performed. Umpolung aminocarbonylation: The first palladium-catalyzed carbonylative cross-coupling between N-chloroamines and organoboronic acids has been realized. Various amides were isolated in moderate to excellent yields from reactions under mild temperatures with ligand-free Pd/C as the catalyst. Not only arylboronic acids, but also alkenyl- and alkylboronic acids are applied as the substrates and bromide and iodide substituents in the substrates are well tolerated.

N-tetrahydrofurfuryl-3,5-dimethylbenzamide

This application is directed to novel compounds useful as insect repellents. The compounds of this invention have the following generic formula: SPC1 Wherein R is selected from the group consisting of hydrogen, alkyl, alkoxyalkyl, alkenyl, and cyanoalkyl;