59512-25-3

Basic information

• Product Name: N-2-(p-isobutylphenyl)propionylurea
• CAS NO: 59512-25-3
• Molecular Weight: 248.325
• Mol File: 59512-25-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-2-(p-isobutylphenyl)propionylurea(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-(p-isobutylphenyl)propionylurea(59512-25-3)
• EPA Substance Registry System: N-2-(p-isobutylphenyl)propionylurea(59512-25-3)

Safety Data

• Hazardous Substances Data: 59512-25-3(Hazardous Substances Data)

Upstream product

• 71381-91-4 (+/-)-2-(4-isobutylphenyl)propanoyl chloride 
• 57-13-6 urea 

Downstream Products

• 70920-04-6 N-2-(p-isobutylphenyl)-propionyl-N'-MMU 

Relevant articles and documents

2-ARYL-PROPIONAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

(R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B 1 pathway.

Synthesis and pharmacological evaluation of N'-morpholinomethylurea derivatives with platelet antiaggregant activity

In the attempt to prolong and stabilize the known antiaggregant activity of morpholinomethylurea (MMU) derivatives were prepared with carboxylic acids possessing antiaggregant, antiinflammatory or hypolipemic activity. The results of the experiments showed the important anti-aggregant and hypolipemic activity of N-2(p-chlorophenoxy)-isobutyryl-N'-morpholinomethylurea (plafibride, ITA 104). The results obtained seem to indicate that the activity of these new N-acyl-N'-MMU is due initially to the molecule per se although it cannot be totally ruled out that part of the pharmacodynamic effect of the MMU may depend on a prodrug-like behaviour.