59543-79-2

Basic information

• Product Name: (2-imidazol-1-yl-ethyl)-xanthen-9-yl-amine
• Synonyms: (2-imidazol-1-yl-ethyl)-xanthen-9-yl-amine
• CAS NO: 59543-79-2
• Molecular Weight: 291.352
• Mol File: 59543-79-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-imidazol-1-yl-ethyl)-xanthen-9-yl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-imidazol-1-yl-ethyl)-xanthen-9-yl-amine(59543-79-2)
• EPA Substance Registry System: (2-imidazol-1-yl-ethyl)-xanthen-9-yl-amine(59543-79-2)

Safety Data

• Hazardous Substances Data: 59543-79-2(Hazardous Substances Data)

Upstream product

• 5739-10-6 N-[2-(aminoethyl)]imidazole 
• 35598-76-6 9-hydroxy-9H-xanthenyl acetate 

Relevant articles and documents

Gastric antisecretory 9H-xanthen-9-amines

A series of 9H-xanthen-9-amines possessing a wide variety of nitrogen substituents at C-9 was prepared for evaluation of gastric antisecretory activity. These substituents included the acetamidine, imidate, pyrimidine, thiazoline, quinuclidine, 2-hydrazinopyridine, aminopiperidine, aminoalkylimidazole, and aminoalkylpyridine moieties. The majority of compounds in this series inhibited gastric acid secretion when tested orally in the pylorus-ligated rat. Potency was increased by intraduodenal administration and diminished by incubation with gastric juice, suggesting partial degradation of the compounds in the gastric environment. A representative example, 3-(9H-xanthen-9-ylamino)-1-ethylpiperidine, exhibited similar activity in dogs, although no free compound could be detected in the blood. It is therefore hypothesized that this compound is either rapidly bound to tissue and/or metabolized to an active species.