59577-13-8

Basic information

• Product Name: Benzenepropanenitrile, 2-hydroxy-
• CAS NO: 59577-13-8
• Molecular Formula: C9H9NO
• Molecular Weight: 147.177
• Mol File: 59577-13-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenepropanenitrile, 2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanenitrile, 2-hydroxy-(59577-13-8)
• EPA Substance Registry System: Benzenepropanenitrile, 2-hydroxy-(59577-13-8)

Safety Data

• Hazardous Substances Data: 59577-13-8(Hazardous Substances Data)

Upstream product

• 107-13-1 acrylonitrile 
• 108-95-2 phenol 
• 90-02-8 salicylaldehyde 
• 409061-86-5 3-(2-hydroxyphenyl)propenenitrile 
• 59577-11-6 3-(2-acetoxy-phenyl)-propionic acid amide 
• 22367-76-6 3-(2-hydroxyphenyl)-propionamide 
• 15119-34-3 3-cyanocoumarin 
• 59577-12-7 3-(2-acetoxy-phenyl)-propionitrile 

Downstream Products

• 1426943-28-3 3-(2-hydroxy-5-iodophenyl)propanenitrile 
• 1426943-15-8 2-(2-cyanoethyl)-4-iodophenyl trifluoromethanesulfonate 
• 90765-59-6 2-Hydroxy-γ-phenylpropyl-amin 
• 152120-04-2 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile 
• 495-78-3 3-(2-hydroxyphenyl)propionic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent β2-adrenoceptor agonists

A series of β2-adrenoceptor agonists with an 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one moiety is presented. The stimulatory effects of the compounds on human β2-adrenoceptor and β1-adrenoceptor were characterized by a cell-based assay. Their smooth muscle relaxant activities were tested on isolated guinea pig trachea. Most of the compounds were found to be potent and selective agonists of the β2-adrenoceptor. One of the compounds, (R)-18c, possessed a strong β2-adrenoceptor agonistic effect with an EC50 value of 24 pM. It produced a full and potent airway smooth muscle relaxant effect same as olodaterol. Its onset of action was 3.5 min and its duration of action was more than 12 h in an in vitro guinea pig trachea model of bronchodilation. These results suggest that (R)-18c is a potential candidate for long-acting β2-AR agonists.

CYCLIC PEROXIDE OXIDATION OF AROMATIC COMPOUND PRODUCTION AND USE THEREOF

The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C-H bonds and one or more activated C-H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C-H bonds; oxidizing selectively one of the one or more aromatic C-H bonds in preference to the one or more activated C-H bonds; adding a hydroxyl group to the one of the one or more aromatic C-H bonds to form one or more phenols; and purifying the one or more phenols.