59645-78-2

Basic information

• Product Name: 7-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline
• Synonyms: 7-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline
• CAS NO: 59645-78-2
• Molecular Weight: 253.344
• Mol File: 59645-78-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline(59645-78-2)
• EPA Substance Registry System: 7-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline(59645-78-2)

Safety Data

• Hazardous Substances Data: 59645-78-2(Hazardous Substances Data)

Upstream product

• 41789-95-1 1-(3-methoxyphenyl)-N-methylmethanamine 
• 16928-30-6 N-(3-methoxybenzylidene)methanamine 
• 591-31-1 3-methoxy-benzaldehyde 
• 128942-63-2 2-[(3-methoxy-benzyl)-methyl-amino]-1-phenyl-ethanol 
• 128942-57-4 2-[(3-Methoxy-benzyl)-methyl-amino]-1-phenyl-ethanone 
• 532-27-4 1-chloroacetophenone 

Relevant articles and documents

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41.

A New Synthesis of 1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines

1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines 6 are obtained from aromatic aldehydes 1, methyl amine and α-haloacetophenones 2 in the presence of sodium borohydride followed by cyclization with sulfuric acid and zinc in methanol.