596846-89-8Relevant articles and documents
Synthesis of hydrophobic phase-tagged prolyl peptides featuring rapid reaction/separation
Chiba, Kazuhiro,Sugihara, Mari,Yoshida, Kazumi,Mikami, Yuzuru,Kim, Shokaku
experimental part, p. 8014 - 8020 (2009/12/06)
Hydrophobically tagged prolyl peptides were synthesized using an electrochemically modified prolyl moiety. The hydrophobic tag served a useful handle for the repetitive reaction/separation steps during solution-phase peptide synthesis. Furthermore, the ta
Synthesis of new bicyclic lactam peptidomimetics by ring-closing metathesis reactions
Colombo, Lino,Di Giacomo, Marcello,Vinci, Valerio,Colombo, Matteo,Manzoni, Leonardo,Scolastico, Carlo
, p. 4501 - 4513 (2007/10/03)
An efficient and versatile synthetic method for the preparation of new fused bicyclic lactams 3a and 3b is described. The spirane cyclopentane nucleus was easily installed by diallylation of the pyroglutamate derivative 18 followed by ring-closing metathe