59698-38-3

Basic information

• Product Name: 4-(3-phenyl-propyl)-piperazine-1-carboxylic acid ethyl ester
• CAS NO: 59698-38-3
• Molecular Weight: 276.379
• Mol File: 59698-38-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-phenyl-propyl)-piperazine-1-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-phenyl-propyl)-piperazine-1-carboxylic acid ethyl ester(59698-38-3)
• EPA Substance Registry System: 4-(3-phenyl-propyl)-piperazine-1-carboxylic acid ethyl ester(59698-38-3)

Safety Data

• Hazardous Substances Data: 59698-38-3(Hazardous Substances Data)

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 104-52-9 phenylpropyl chloride 

Downstream Products

• 55455-92-0 1-(3-phenylpropyl)piperazine 

Relevant articles and documents

Synthesis and structure-activity relationships of novel 2-amino alkyl chromones and related derivatives as σ site-selective ligands

Starting from a random screening showing that 2-[(4- benzylpiperazinyl)methyl] chromone was a selective and potent sigma ligand, a series of analogues were synthesized. Introduction of a substituent on the chromone moiety, replacement of methylenes by carbonyl groups and benzyl by aryl groups decrease the affinity for sigma sites. The result obtained after introduction of various substituents on the aromatic part of the benzyl is strictly depending on the size and on the position of these substituents. Stretching of the carbon chain between the phenyl and the piperazine does not strongly modify the affinity. 2-[4-(4'-methoxy benzyl)1-piperazinyl methyl] chromone has been tested in behavioral tests that permit to believe that such derivatives could be interesting for the treatment of psychosis.