59749-18-7

Basic information

• Product Name: methyl 1-(4-chlorobenzyl)-5-oxo-L-prolinate
• Synonyms: L-proline, 1-[(4-chlorophenyl)methyl]-5-oxo-, methyl ester
• CAS NO: 59749-18-7
• Molecular Formula: C₁₃H₁₄ClNO₃
• Molecular Weight: 267.7082
• Mol File: 59749-18-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 424.1°C at 760 mmHg
• Flash Point: 210.3°C
• Density: 1.311g/cm³
• Vapor Pressure: 2.12E-07mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: methyl 1-(4-chlorobenzyl)-5-oxo-L-prolinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(4-chlorobenzyl)-5-oxo-L-prolinate(59749-18-7)
• EPA Substance Registry System: methyl 1-(4-chlorobenzyl)-5-oxo-L-prolinate(59749-18-7)

Safety Data

• Hazardous Substances Data: 59749-18-7(Hazardous Substances Data)

Upstream product

• 4931-66-2 methyl (S)-pyroglutamate 
• 98-79-3 L-Pyroglutamic acid 
• 622-95-7 4-chlorobenzyl bromide 

Downstream Products

• 116404-24-1 (S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid 
• 1615249-83-6 tert-butyl ((S)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate 
• 1615249-84-7 tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate 

Relevant articles and documents

Synthesis and evaluation of dual antiplatelet activity of bispidine derivatives of N-substituted pyroglutamic acids

N-aralkylpyroglutamides of substituted bispidine were prepared and evaluated for their ability to inhibit collagen induced platelet aggregation, both in vivo and in vitro. Some compounds showed high anti-platelet efficacy (in vitro) of which six inhibited

Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice

The protection by pyroglutamic acid (CAS 98-79-3) and derivatives Ia-i (injected i.p.) against glutamate- and NMDA (N-methyl-D-aspartate) (i.c.v.) induced seizures in mice has been studied in comparison with known antiepileptics and antagonists of excitatory aminoacids. The potency of pyroglutamic acid and some derivatives (Id,f,g,h) against glutamate-induced convulsions was similar to that shown by glutamic acid diethylester and by valproic acid. Interestingly, pyroglutamic acid did not affect NMDA-induced convulsions which were well antagonized by both 2-amino-5-phosphono valeric acid and by diazepam. Thus, pyroglutamic acid may represent the starting for synthesis of excitatory aminoacid antagonists acting at non NMDA receptors.