59758-29-1

Basic information

• Product Name: 5-(2-chlorophenyl)-2-hydrazino-1,3,4-thiadiazole
• Synonyms: 5-(2-chlorophenyl)-2-hydrazino-1,3,4-thiadiazole
• CAS NO: 59758-29-1
• Molecular Weight: 226.689
• Mol File: 59758-29-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(2-chlorophenyl)-2-hydrazino-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-chlorophenyl)-2-hydrazino-1,3,4-thiadiazole(59758-29-1)
• EPA Substance Registry System: 5-(2-chlorophenyl)-2-hydrazino-1,3,4-thiadiazole(59758-29-1)

Safety Data

• Hazardous Substances Data: 59758-29-1(Hazardous Substances Data)

Upstream product

• 5814-05-1 2-chlorobenzoylhydrazide 
• 36894-93-6 2-chloro-5-(2-chlorophenyl)-1,3,4-thiadiazole 
• 57709-56-5 2-bromo-5-(2-chloro-phenyl)-[1,3,4]thiadiazole 

Downstream Products

• 59758-65-5 2-[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-5-phenyl-2H-pyrazol-3-ylamine 
• 59758-51-9 {[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-hydrazono}-phenyl-acetic acid 
• 59758-37-1 2-{[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-hydrazono}-propionic acid ethyl ester 
• 104070-66-8 N-[5-(2-Chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-N-methoxymethyl-hydrazine 
• 1186014-28-7 C₁₆H₁₃ClN₄OS 
• 1186014-27-6 C₁₅H₁₁ClN₄OS 
• 473725-86-9 4-[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-ylamino]-1-thia-4-aza-spiro[4.5]decan-3-one 
• 473725-42-7 N-[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-N'-cyclohexylidene-hydrazine 
• 104070-90-8 N-[5-(2-Chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-N'-phenyl-hydrazine 
• 59758-44-0 2-{[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-hydrazono}-propionic acid 
• 59758-60-0 7-(2-chloro-phenyl)-3-phenyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one 
• 104071-09-2 N-Benzyl-N-[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-N'-methyl-hydrazine 
• 104070-91-9 N-Benzyl-N'-[5-(2-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-hydrazine 
• 104071-06-9 N-[5-(2-Chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-N'-cyclopentyl-N-methyl-hydrazine 

Relevant articles and documents

Synthesis and spectral characterization of Zn(II) microsphere series for antimicrobial application

Microsphere series have been synthesized by reacting zinc(II) acetate dihydrate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole/oxadiazole/triazole with salicylaldehyde. Elemental analysis suggests that the complexes have 1:2 and 1:1 stoichiometry of the type [Zn(L)2(H2O)2] and [Zn(L′)(H 2O)2]; LH = Schiff bases derived from 2-hydrazino-5- [substituted phenyl]-1,3,4-thia/oxadiazole with salicylaldehyde; L′H 2 = Schiff bases derived from 3-(substituted phenyl)-4-amino-5- hydrazino-1,2,4-triazole and salicylaldehyde and were characterized by elemental analyses, IR, 1H NMR and 13C NMR spectral data. Scanning electron microscopy (SEM) showed that synthesized materials have microsphere like structure and there EDX analysis comparably matches with elemental analysis. For the antimicrobial application Schiff bases and their zinc(II) complexes were screened for four bacteria e.g. Bacillus subtilis, Pseudomonas aeruginosa, Salmonella typhi, Streptococcus pyogenes and four fungi e.g. Cyrtomium falcatum, Aspergillus niger, Fusarium oxysporium and Curvularia pallescence by the reported method. Schiff base and Zn(II) compounds showed significant antimicrobial activities. However, activities increase upon chelation. Thermal analysis (TGA) data of compound (10) showed its stability up to 300 °C.

Substituted 1,3,4-Thiadiazoles with Anticonvulsant Activity. 1. Hydrazines

The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described.The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine.