59769-37-8

Basic information

• Product Name: (4-Fluorophenoxy)acetaldehyde Diethyl Acetal
• Synonyms: (4-Fluorophenoxy)acetaldehyde Diethyl Acetal;1-(2,2-Diethoxy-ethoxy)-4-fluoro-benzene
• CAS NO: 59769-37-8
• Molecular Formula: C₁₂H₁₇FO₃
• Molecular Weight: 228.2599832
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 59769-37-8.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, DCM, Ethyl Acetate
• CAS DataBase Reference: (4-Fluorophenoxy)acetaldehyde Diethyl Acetal(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Fluorophenoxy)acetaldehyde Diethyl Acetal(59769-37-8)
• EPA Substance Registry System: (4-Fluorophenoxy)acetaldehyde Diethyl Acetal(59769-37-8)

Safety Data

• Hazardous Substances Data: 59769-37-8(Hazardous Substances Data)

Usage

Description

(4-Fluorophenoxy)acetaldehyde Diethyl Acetal is an organic compound belonging to the N-Aryloxyethylindolylalkylamine class. It is characterized by its dual affinity for the 5-HT1A receptor and the serotonin transporter, making it a potentially valuable molecule in the field of pharmaceuticals and neuroscience.

Uses

Used in Pharmaceutical Industry:
(4-Fluorophenoxy)acetaldehyde Diethyl Acetal is used as a therapeutic agent for the treatment of various psychiatric and neurological disorders due to its dual affinity for the 5-HT1A receptor and the serotonin transporter. This unique property allows it to potentially modulate serotonin levels in the brain, which can be beneficial for conditions such as depression, anxiety, and other mood disorders.
Used in Research and Development:
In the field of research, (4-Fluorophenoxy)acetaldehyde Diethyl Acetal serves as a valuable tool for studying the interactions between the 5-HT1A receptor and the serotonin transporter. This can help scientists better understand the underlying mechanisms of various psychiatric and neurological disorders, as well as develop more targeted and effective treatments.
Used in Drug Design and Optimization:
The dual affinity of (4-Fluorophenoxy)acetaldehyde Diethyl Acetal for the 5-HT1A receptor and the serotonin transporter makes it a promising starting point for the design and optimization of new drugs. Researchers can use this molecule as a template to develop more potent and selective compounds with improved pharmacological properties, potentially leading to the discovery of novel therapeutic agents for a range of conditions.

Upstream product

• 371-41-5 4-Fluorophenol 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 621-62-5 chloroacetaldehyde diethyl acetal 

Downstream Products

• 59769-38-9 2-(4-fluorophenoxy)acetaldehyde 
• 62020-11-5 5-(4-fluorophenoxy)-1-penten-4-ol 
• 24410-59-1 5-Fluoro[b]benzofuran 
• 245762-36-1 5-fluoro-2,3-dihydrobenzofuran-7-carbaldehyde 
• 245762-35-0 5-fluoro-2,3-dihydrobenzofuran 
• 245762-37-2 5-fluoro-7-hydroxy-2,3-dihydrobenzofuran 
• 41964-00-5 5-(4-fluoro-phenoxy)-1H-pyrimidin-2-one 
• 62020-20-6 4-benzyloxy-5-(4-fluorophenoxy)-1-pentene 
• 62020-12-6 4-benzyloxy-5-(4-fluorophenoxy)-1-pentanol 
• 62020-10-4 4-benzyloxy-5-(4-fluorophenoxy)-1-iodopentane 
• 62020-08-0 8-methylsulfonyl-12-hydroxy-13-(4-fluorophenoxy)tridecanoic acid 
• 62020-07-9 12-Benzyloxy-13-(4-fluoro-phenoxy)-8-methanesulfonyl-tridecanoic acid 
• 62020-22-8 methyl 8-methylsulfonyl-12-benzyloxy-13-(4-fluorophenoxy)tridecanoate 
• 62020-21-7 methyl 8-methylsulfonyl-8-methoxycarbonyl-12-benzyloxy-13-(4-fluorophenoxy)tridecanoate 

Relevant articles and documents

Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

Visible light-induced monofluoromethylenation of heteroarenes with ethyl bromofluoroacetate

Visible light-induced monofluoromethylenation of benzofurans and benzothiophenes with ethyl bromofluoroacetate was developed. This method provided a convenient access to novel α-fluoro-α-heteroarylesters under mild reaction conditions.