59782-90-0Relevant articles and documents
Method for efficiently synthesizing pyridine chlorides
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Paragraph 0025-0027; 0030-0032; 0035-0037; 0040-0042; 0045, (2020/06/09)
The invention discloses a method for efficiently synthesizing a pyridine chloride. The method comprises the following steps: introducing chlorine into methylpyridine in a solvent, and activating witha ligand catalyst; and after the activation is finished, separating and removing the solvent to obtain activated methylpyridine, carrying out a chlorine gas introduction reaction at a certain temperature, and after the reaction is finished, carrying out distillation separation to obtain 2,3-dichloro-5-trichloromethylpyridine. According to the process disclosed by the invention, methylpyridine is firstly activated by adopting an efficient ligand catalyst, then chlorine is introduced for chlorination, the chlorination process has high selectivity, the reaction condition is mild, the equipment operation is simple, few polychlorinated impurities are generated in the reaction process, and the process has high operability and economical efficiency.
Rh/Pd catalysis with chiral and achiral ligands: Domino synthesis of aza-dihydrodibenzoxepines
Friedman, Adam A.,Panteleev, Jane,Tsoung, Jennifer,Huynh, Vaizanne,Lautens, Mark
supporting information, p. 9755 - 9758 (2013/09/23)
A game of dominoes: A synthetic route to aza-dihydrodibenzoxepines is described, through the combination of a Rh-catalyzed arylation and a Pd-catalyzed C-O coupling in a single pot. For the first time, the ability to incorporate a chiral and an achiral ligand in a two-component, two-metal transformation is achieved, giving the products in moderate to good yields, with excellent enantioselectivities. Copyright
Synthesis of Halogenated Pyridines via the CuCl-Catalyzed Addition of Polyhaloacetonitriles to Olefins
Pews, R. Garth,Lysenko, Zenon
, p. 5115 - 5119 (2007/10/02)
Halogenated acetonitriles add smoothly to acrolein, methacrolein, and methacrolein dimethyl acetal in the presence of a catalytic amount of CuCl and triphenylphosphine, tri-n-butylphosphine, or triethylamine to give halogenated difunctional adducts.The adducts have been cyclized in high yields under acidic conditions to halogenated pyridines.