59798-30-0 Usage
Description
Mezlocillin sodium, a derivative of penicillin, is a β-lactam antibiotic known for its antimicrobial properties. It is effective against a range of bacteria, including B. fragilis, E. lentum, P. morbillorum, and F. nucleatum. Mezlocillin sodium is a white to slightly yellow crystalline powder and is marketed under the brand name Mezlin by Bayer.
Uses
1. Used in Pharmaceutical Industry:
Mezlocillin sodium is used as an antimicrobial agent for treating various bacterial infections. Its effectiveness against a range of bacteria, such as B. fragilis, E. lentum, P. morbillorum, and F. nucleatum, makes it a valuable component in the development of antibiotics for medical use.
2. Used in Antimicrobial Formulations:
Mezlocillin sodium is used as an active ingredient in formulations designed to combat bacterial infections. Its ability to increase survival rates and reduce bacteremia in animal models of endocarditis and pulmonary infections highlights its potential in creating effective treatments for similar conditions in humans.
3. Used in Research and Development:
Mezlocillin sodium serves as a valuable compound for researchers studying the properties and mechanisms of β-lactam antibiotics. Its activity against specific bacteria and its role in enhancing the efficacy of conventional chemotherapeutic drugs make it an important subject for further investigation and potential development of new antimicrobial agents.
Clinical Use
Mezlocillin (Mezlin) is an acylureidopenicillin with an antibacterialspectrum similar to that of carbenicillin andticarcillin; however, there are some major differences. It ismuch more active against most Klebsiella spp., P. aeruginosa,anaerobic bacteria (e.g., Streptococcus faecalis andB. fragilis), and H. influenzae. It is recommended for thetreatment of serious infections caused by these organisms.Mezlocillin is not generally effective against β-lactamase–producing bacteria, nor is it active orally. It isavailable as a white, crystalline, water-soluble sodium saltfor injection. Solutions should be prepared freshly and, ifnot used within 24 hours, refrigerated. Mezlocillin and otheracylureidopenicillins, unlike carbenicillin, exhibit nonlinearpharmacokinetics. Peak plasma levels, half-life, and areaunder the time curve increase with increased dosage.Mezlocillin has less effect on bleeding time than carbenicillin,and it is less likely to cause hypokalemia.
Check Digit Verification of cas no
The CAS Registry Mumber 59798-30-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,7,9 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 59798-30:
(7*5)+(6*9)+(5*7)+(4*9)+(3*8)+(2*3)+(1*0)=190
190 % 10 = 0
So 59798-30-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H25N5O8S2.Na/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34;/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30);/q;+1/p-1
