598-45-8 Usage
Description
I-PROPYLISOCYANIDE, also known as an alkyl isocyanide, is an organic compound characterized by the presence of an isocyanide functional group. It is a versatile building block in organic synthesis and has various applications across different industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
I-PROPYLISOCYANIDE is used as a key intermediate for the synthesis of Ugi ligand A2C11I1, which is employed in the solid-phase Ugi synthesis. This application is significant for the development of new pharmaceutical compounds and drug candidates.
Used in Polymer Industry:
I-PROPYLISOCYANIDE is used as a monomer for the preparation of Pentafluorophenyl (PFP) functional monomers via the Passerini reaction. These monomers are essential for the development of advanced polymer materials with specific properties tailored for various applications.
Used in Coordination Chemistry:
I-PROPYLISOCYANIDE is used as a building block for the synthesis of Dinuclear copper complex [Cu2(μ-PiPr2bipy)2μ-CNCH(CH3)2](PF6)2 [PiPr2bipy = 6-(diisopropylphosphanyl)-2,2′-bipyridine]. This complex has potential applications in coordination chemistry and materials science.
Used in Organic Synthesis:
I-PROPYLISOCYANIDE is used as a reactant for the preparation of (3E)-(Imino)thiaisoindoline 1,1-dioxide derivative, N,N′-diisopropylcarbodiimide (DIC) analog via reaction with propan-2-amine, 1-t-butyl-2-isopropyldiaziridinone via reaction with 2-methyl-2-nitrosopropane, and isopropyl isocyanide via reaction with ozone. These compounds have potential applications in various organic synthesis processes.
Used in Chemical Research:
I-PROPYLISOCYANIDE is used as a reactant in the synthesis of 1-phthalimidoazetidines via [1+3]cycloaddition reaction with 1-pththalimidoaziridines. This reaction is of interest to researchers in the field of chemical synthesis and material development.
Preparation
To a flask containing 100 ml (0.85 mole) of distilled quinoline is added with stirring 41 gm (0.214 mole) of /7-toluenesulfonyl chloride (see Note), and the solution is warmed to 75°C. Then 18.4 gm (0.212 mole) of isopropylformamide is added and the pressure of the system is reduced to 70 mm Hg. The isopropylisonitrile as it forms distills into a liquid nitrogencooled receiver. (Dry ice is not as effective but may be used.) The product is redistilled to afford 4.2 gm (30%), b.p. 88-89°C (735 mm Hg).
Check Digit Verification of cas no
The CAS Registry Mumber 598-45-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 598-45:
(5*5)+(4*9)+(3*8)+(2*4)+(1*5)=98
98 % 10 = 8
So 598-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N/c1-4(2)5-3/h4H,1-2H3
598-45-8Relevant articles and documents
Photochemical Reactivity of Aldimines from 2,2-Dimethyl-3-oxo-3-phenylpropanal
Armesto, Diego,Ramos, Ana,Perez-Ossorio, Rafael,Horspool, William M.
, p. 91 - 94 (2007/10/02)
The syntheses of some thermally labile aldimines of 2,2-dimethyl-3-oxo-3-phenylpropanal are described.The aldimines (7a-c) are photochemically reactive and undergo fission mainly into isopropyl phenyl ketone.Several other minor products are also formed.On
