59852-99-2

Basic information

• Product Name: Phosphonic acid, [(4-methylphenyl)(phenylamino)methyl]-, dimethyl ester
• CAS NO: 59852-99-2
• Molecular Formula: C16H20NO3P
• Molecular Weight: 305.313
• Mol File: 59852-99-2.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [(4-methylphenyl)(phenylamino)methyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [(4-methylphenyl)(phenylamino)methyl]-, dimethyl ester(59852-99-2)
• EPA Substance Registry System: Phosphonic acid, [(4-methylphenyl)(phenylamino)methyl]-, dimethyl ester(59852-99-2)

Safety Data

• Hazardous Substances Data: 59852-99-2(Hazardous Substances Data)

Upstream product

• 96-36-6 methyl phosphite 
• 2362-77-8 (4-methylbenzylidene)phenylamine 
• 104-87-0 4-methyl-benzaldehyde 
• 62-53-3 aniline 
• 15818-64-1 N-(4-methylbenzyl)aniline 
• 868-85-9 Dimethyl phosphite 
• 98-95-3 nitrobenzene 
• 121-45-9 phosphorous acid trimethyl ester 
• 67-56-1 methanol 

Relevant articles and documents

Design and preparation of HPW-anchored magnetic carbon nitride nanosheets: an efficient and eco-friendly nanocomposite for one-pot synthesis of α-amino phosphonates

Heterogeneous catalysis is one of the fastest and greatest developing branches and longstanding challenges in academic researchers and the chemical industry. Carbon-based material with various functional groups, the most abundant elements, and the main component in natural products provide a unique platform for heterogeneous catalysis due to their excellent biocompatibility and high performance. Herein, we introduce a novel nanocomposite comprising of different acids anchored to magnetic mesoporous carbon nitrides through a grindstone method to enhance nanocomposite catalysts’ environmentally benign capability. As a result, the obtained porous magnetic catalysts show the highest possible activity and product selectivity for facile preparation of α-amino phosphonates derivatives in good to excellent yields at ambient temperature. This fast and straightforward methodology offers pot economy for the satisfactory reaction of various aldehyde, amine, and triaryl and trialkyl phosphite with a broad range of functional groups in a gram scale under mild reaction conditions.

Synthetic method of alpha-amino phosphonate

A synthetic method for preparing alpha-amino phosphonate by direct oxidation of secondary amines by DDQ is disclosed. According to the method, the product is prepared by oxidative dehydrogenation coupling phosphonic acid esterification reaction of various secondary amines as raw materials, various phosphinates as phosphonic acid esterification reagents and the DDQ as an oxidant in a solvent, quenching, extraction, concentration and purification. A novel synthesis method aiming at overcoming the defects of the existing synthesis method of the alpha-amino phosphonate is provided, the alpha-aminophosphonate product is prepared by direct DDQ oxidation without transition metal catalysis, the phosphonic acid esterification reaction of the various secondary amines and the various phosphinates can be efficiently realized, alpha-amino phosphonate substances with high yield and diverse structures can be prepared by the method, and the method has the advantages of being simple in method, short in reaction time, simple and convenient to operate, energy-saving, low in production cost, atom-economic, and beneficial to industrialization and the like.

Formic acid catalyzed one-pot synthesis of α-aminophosphonates: an efficient, inexpensive and environmental friendly organocatalyst

Abstract: Aqueous formic acid is used for the synthesis of α-aminophosphonates through Kabachnik–Fields reaction applying aromatic amine, phosphite, and carbonyl compounds. Using formic acid as an efficient and low-cost organocatalyst provides environmental friendly, high yields, low reaction time and mild reaction condition. The isolated products were analyzed by IR, NMR, and mass techniques. Graphical abstract: [Figure not available: see fulltext.].