59864-31-2

Basic information

• Product Name: 2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-
• Synonyms: 2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-;1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid
• CAS NO: 59864-31-2
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Mol File: 59864-31-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 247-248 °C
• Boiling Point: 369.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.381±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.76±0.20(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-(59864-31-2)
• EPA Substance Registry System: 2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-(59864-31-2)

Safety Data

• Hazardous Substances Data: 59864-31-2(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- is also known as niacinamide or nicotinamide. It is a form of vitamin B3, and it is important for the function of the nervous system, digestive system, and skin health. Niacinamide is commonly used in skincare products for its ability to improve the appearance of acne, rosacea, pigmentation, and fine lines. It also has anti-inflammatory and antioxidant properties, making it beneficial for overall skin health. In addition to its skincare benefits, niacinamide is also used as a nutritional supplement to treat and prevent vitamin B3 deficiency.

Upstream product

• 20845-22-1 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester 
• 74-88-4 methyl iodide 
• 19621-92-2 2-oxo-1,2-dihydropyridine-6-carboxylic acid 
• 19621-92-2 6-Hydroxypicolinic acid 

Downstream Products

• 694-85-9 1-methyl-2-pyridone 

Relevant articles and documents

Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy

A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, the multiply substituted 2-pyridone can be prepared via sequential C-H functionalization reactions.

MORPHINAN DERIVATIVE

A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(=O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.

Accelerated decarboxylation of 1,3-dimethylorotic acid in ionic liquid

The solvent effect of ionic liquids on the decarboxylation of 1,3-dimethylorotic acid and its analogue in ionic was investigated. The rate acceleration observed was proposed to be a result of the stabilization of the zwitterionic intermediates by the charged groups available in these special solvents.