59865-15-5

Basic information

• Product Name: DIHYDROCYCLOSPORIN A
• Synonyms: DIHYDROCYCLOSPORIN A;Dihydrocyclosporin;(3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-];(3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A;Cyclosporin A Dihydro IMpurity;Dihydrocyclosporine A
• CAS NO: 59865-15-5
• Molecular Formula: C62H113N11O12
• Molecular Weight: 1204.63
• Product Categories: Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
• Mol File: 59865-15-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 120-125?C
• Boiling Point: 1285.277oC at 760 mmHg
• Flash Point: 731.109oC
• Appearance: /
• Density: 1.012g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 13.33±0.70(Predicted)
• CAS DataBase Reference: DIHYDROCYCLOSPORIN A(CAS DataBase Reference)
• NIST Chemistry Reference: DIHYDROCYCLOSPORIN A(59865-15-5)
• EPA Substance Registry System: DIHYDROCYCLOSPORIN A(59865-15-5)

Safety Data

• Hazardous Substances Data: 59865-15-5(Hazardous Substances Data)

Usage

Description

Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A, characterized by its white solid chemical properties. Unlike cyclosporin A, it does not exhibit any immunosuppressant activity, making it a valuable control in determining the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.

Uses

Used in Pharmaceutical Research:
Dihydrocyclosporin A is used as a control substance for [application reason] to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.
Used in Immunosuppressive Drug Development:
As an analog of cyclosporin A, Dihydrocyclosporin A is used as a reference compound for [application type] in the development of new immunosuppressive drugs, aiding in understanding the differences in their mechanisms of action and potential therapeutic applications.

InChI:InChI=1/C62H113N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h34-47,49-52,75H,25-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/t40-,41+,42-,43+,44+,45+,46-,47+,49+,50+,51?,52-/m1/s1

Upstream product

• 59865-13-3 C₆₂H₁₁₁N₁₁O₁₂ 
• 59865-13-3 cyclosporine A 
• 121584-52-9 C₆₂H₁₀₉N₁₁O₁₄ 
• 83563-94-4 C₆₄H₁₁₃N₁₁O₁₃ 
• 83563-94-4 C₆₄H₁₁₃N₁₁O₁₃ 
• 59865-13-3 cyclosporin A 

Relevant articles and documents

Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives

In order to exploit cyclophilin as a potential target for neurological drug design, we demonstrate in this presentation that several nonimmunosuppressant analogues of cyclosporin A, modified at the various positions in the 'effector' domain, are equipotent nerve growth agents compared to cyclosporin A. Our results suggest that neurotrophic activity of cyclosporin A and its derivatives resides in the binding domain, and binding to cyclophilin and/or inhibiting rotamase activity may be a necessity for neurotrophic effects of cyclophilin ligands.