599183-43-4Relevant articles and documents
INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS
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Page/Page column 271; 272, (2021/01/29)
The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.
In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors
Wood, Spencer D.,Grant, Wayne,Adrados, Isabel,Choi, Jun Yong,Alburger, James M.,Duckett, Derek R.,Roush, William R.
, p. 1258 - 1263 (2017/12/26)
We present the outcome of an in silico high throughput screen (HTS) and optimization of a small molecule Unc-51-Like Kinase 1 (ULK1) inhibitor hit, SR-17398, with an indazole core. Docking studies guided design efforts that led to inhibitors with increase
Substituted indazoles, compositions containing them, method of production and use
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, (2008/06/13)
Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particlar in onco