59946-31-5

Basic information

• Product Name: C₁₅H₁₉NO₄
• Synonyms: C₁₅H₁₉NO₄
• CAS NO: 59946-31-5
• Molecular Weight: 277.32
• Mol File: 59946-31-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₉NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₉NO₄(59946-31-5)
• EPA Substance Registry System: C₁₅H₁₉NO₄(59946-31-5)

Safety Data

• Hazardous Substances Data: 59946-31-5(Hazardous Substances Data)

Upstream product

• 759-65-9 diethyl oxalpropionate 
• 62-53-3 aniline 

Downstream Products

• 219949-95-8 ethyl 3-methyl-4-oxo-1,4‐dihydroquinoline‐2‐carboxylate 

Relevant articles and documents

Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors

Calpains are involved in a variety of calcium-regulated cellular processes, such as signal transduction, cell proliferation, differentiation, and apoptosis. Excessive calpain activation contributes to serious cellular damage and has been reported in many pathological conditions. 4-Quinolinone 2-carboxamide derivatives were prepared and evaluated for μ-calpain inhibitory activities. Of the compounds synthesized, 3a and 3k, which possess a primary amide and 4-methoxyphenethyl amide at P1′ region, were found to most potently inhibit μ-calpain with IC50 values of 0.71 ± 0.07 and 0.73 ± 0.23 μM, respectively. On the other hand, the incorporation of pyridine-containing amides decreased inhibitory activity.