59950-56-0

Basic information

• Product Name: 2,2-DIMETHYLPROPIONAMIDINE
• Synonyms: SPECS AG-690/33428046;2,2-DIMETHYLPROPIONAMIDINE;2,2-dimethylpropanimidamide(SALTDATA: HCl)
• CAS NO: 59950-56-0
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.16
• Mol File: 59950-56-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 126.9±23.0 °C(Predicted)
• Appearance: /
• Density: 0.92±0.1 g/cm3(Predicted)
• PKA: 12.87±0.40(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYLPROPIONAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYLPROPIONAMIDINE(59950-56-0)
• EPA Substance Registry System: 2,2-DIMETHYLPROPIONAMIDINE(59950-56-0)

Safety Data

• Hazardous Substances Data: 59950-56-0(Hazardous Substances Data)

Usage

General Description

2,2-Dimethylpropionamidine, also known as N,N-dimethylalanine, is a chemical compound with the molecular formula C5H12N2. It is a derivative of propionamide and is commonly used as a reagent in organic synthesis. 2,2-DIMETHYLPROPIONAMIDINE is widely used as a building block in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical intermediates. It is known for its ability to react with various organic compounds, forming stable covalent bonds and facilitating the formation of complex molecular structures. 2,2-Dimethylpropionamidine is also used as a precursor in the production of other chemicals and is considered to be a valuable synthetic building block.

Upstream product

• 52186-79-5 2,2-dimethyl-propionimidic acid ethyl ester 
• 58910-26-2 ethyl 2,2-dimethylpropanimidoate hydrochloride 
• 630-18-2 tert-butyl isocyanide 

Downstream Products

• 1011464-42-8 ethyl 2-(tert-butyl)-4-chloropyrimidine-5-carboxylate 
• 92325-20-7 4-acetylamino-N-(3-tert-butyl-[1,2,4]thiadiazol-5-yl)-benzenesulfonamide 
• 193610-95-6 2-(1,1-dimethylethyl)-6-trifluoromethylpyrimidin-4-ol 
• 901309-52-2 (5-(3-(3-tert-butyl-1,2,4-thiadiazol-5-ylamino)pyridin-2-yloxy)-3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone 
• 950486-06-3 C₁₉H₂₂N₄O₂S 
• 950485-92-4 C₁₈H₁₉ClN₄OS 
• 950486-07-4 C₁₇H₁₉N₅O₂S 
• 950485-94-6 C₁₆H₁₆ClN₅OS 
• 950486-02-9 C₁₉H₂₂N₄OS 
• 950486-04-1 C₁₇H₁₉N₅OS 
• 950485-89-9 C₁₆H₁₇N₅OS 
• 950485-85-5 C₁₈H₂₀N₄OS 
• 1012331-73-5 C₁₇H₁₉N₅OS 
• 1029234-51-2 C₁₂H₁₆BrN₃S 

Relevant articles and documents

2-Amino-1,3,5-triazine chemistry: hydrogen-bond networks, Takemoto thiourea catalyst analogs, and olfactory mapping of a sweet-smelling triazine

Abstract The chemistry of 4,6-dialkyl-2-amino-1,3,5-triazines with bulky alkyl substituents was investigated and their use as building blocks for preparing chiral thiourea organocatalysts explored. Reaction of ammonia with 4,6-di-tert-butyl-2-chloro-1,3,5-triazine gave 4,6-di-tert-butyl-1,3,5-triazin-2-amine which formed extended hydrogen-bond networks in the solid state according to X-ray crystallography. Selected heterocyclic amines were converted to isothiocyanates, and the latter reacted with (S,S)-2-(dimethylamino)cyclohexylamine to give enantiopure 1-hetaryl-3-[2-(dimethylamino)cyclohexyl]thioureas, with hetaryl representing either 4,6-dimethyl-1,3-diazin-2-yl, 4,6-diisopropyl-1,3,5-triazin-2-yl, or 4,6-di-tert-butyl-1,3,5-triazin-2-yl groups. These compounds are structural analogs of Takemotos's chiral thiourea organocatalysts (1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea) with an aza-aryl instead of the 3,5-bis(trifluoromethyl)phenyl group. They feature a strong intramolecular N-H to N-1 hydrogen bond, as shown by X-ray crystallography of 1-(4,6-di-tert-butyl-1,3,5-triazin-2-yl)-3-[2-(dimethylamino)cyclohexyl]thiourea in the solid state and by 1H NMR spectroscopy of all derivatives in CDCl3 solution, which prevents them from acting as bifunctional organocatalyst. In the reaction of 4,6-di-tert-butyl-2-chloro-1,3,5-triazine with ammonia, 4,6-di-tert-butyl-2-ethoxy-1,3,5-triazine was identified as side-product displaying a mildly sweet, floral odor that is unusual for a 1,3,5-triazine. Analogs (>35) of 4,6-di-tert-butyl-2-ethoxy-1,3,5-triazine were prepared to define the important structural factors of the olfactophore.

Heterocyclic Compounds Useful as RAF Kinase Inhibitors

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.