5998-50-5

Basic information

• Product Name: Benzoxazole, 2-[4-(1,1-dimethylethyl)phenyl]-
• Synonyms: 2-(4-tert-butylphenyl)-benzooxazole;2-(4-tert-Butyl-phenyl)-benzooxazole;2-(4-t-butylphenyl)benzoxazole;2-(4-tert-butylphenyl)-1,3-benzoxazole;2-(4-tert-butylphenyl)benzo[d]oxazole;2-(4-tert-butylphenyl)benzoxazole
• CAS NO: 5998-50-5
• Molecular Formula: C17H17NO
• Molecular Weight: 251.328
• Mol File: 5998-50-5.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: Benzoxazole, 2-[4-(1,1-dimethylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoxazole, 2-[4-(1,1-dimethylethyl)phenyl]-(5998-50-5)
• EPA Substance Registry System: Benzoxazole, 2-[4-(1,1-dimethylethyl)phenyl]-(5998-50-5)

Safety Data

• Hazardous Substances Data: 5998-50-5(Hazardous Substances Data)

Upstream product

• 389840-61-3 N-4-tert-butylbenzylidene-2-hydroxyaniline 
• 73471-97-3 1-(4-(tertbutyl)phenyl)-2,2,2-trifluoroethanone 
• 95-55-6 2-amino-phenol 
• 877-65-6 p-tert-butylbenzyl alcohol 
• 273-53-0 benzoxazole 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 88-75-5 2-hydroxynitrobenzene 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 19692-45-6 4-tert-butylbenzyl chloride 
• 56108-12-4 4-tert-butylbenzamide 
• 108-94-1 cyclohexanone 
• 85609-03-6 phenyl p-(tert-butyl)phenyl sulfide 
• 772-38-3 4-tert-Butylphenylacetylene 

Relevant articles and documents

Delivering 2-Aryl Benzoxazoles through Metal-Free and Redox-Neutral De-CF3Process

An unexpected cleavage of the Csp3-CF3 bond of CF3-hydrobenzoxazoles has been disclosed, affording a range of 2-aryl benzoxazoles under metal-free and redox-neutral conditions. This transformation has demonstrated broad substrate scope and good compatibility of functional groups. 2-Aryl benzothiazole and 2-aryl benzoimidazole could be smoothly assembled in the same manner. On the basis of preliminary mechanistic studies, base initiated and aromatization driven β-carbon elimination was considered to be the key step for the formation of 2. This reaction offers an alternative, facile, and sustainable route to access important 2-aryl benzoxazole motifs.

2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES

A genus of compounds encompassed by formula (III) and their use is disclosed: Formula (III). The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.

Sulfur/DABCO Promoted Reductive Coupling/Annulation Cascade Reaction between o -Hydroxy/Amino Nitrobenzenes and Benzaldehydes

Sulfur/DABCO was found to be an efficient reagent in promoting- the reductive coupling/annulation of o -nitrophenols or o -nitroanilines with benzaldehydes. This method represents a simple, straightforward, and green approach to the construction of benz-oxazoles and benzimidazoles.