60-41-3 Usage
Uses
Chiefly in poison baits for rodents.
General Description
Colorless, odorless, very bitter crystals or white crystalline powder. Has been used as a tonic and stimulant in veterinary medicine. Registered as a rodenticide in the U.S.
Reactivity Profile
STRYCHNINE is an alkaloid derivative. STRYCHNINE is a base and forms water soluble salts with acids. Avoid alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light. [EPA, 1998] STRYCHNINE is incompatible with the following: Strong oxidizers .
Health Hazard
Violent poison!. Lowest published lethal dose orally in humans is 30 mg/kg.
Fire Hazard
When heated to decomposition, STRYCHNINE emits very toxic fumes of sulfur oxides and nitrogen oxides. Avoid alkalies, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light.
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also STRYCHNINE and SULFATES
Check Digit Verification of cas no
The CAS Registry Mumber 60-41-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 60-41:
(4*6)+(3*0)+(2*4)+(1*1)=33
33 % 10 = 3
So 60-41-3 is a valid CAS Registry Number.
InChI:InChI=1/2C21H22N2O2.H2O4S/c2*24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;1-5(2,3)4/h2*1-5,13,16-17,19-20H,6-11H2;(H2,1,2,3,4)
60-41-3Relevant articles and documents
Mechanistic studies on the reaction of nitrocobalamin with glutathione: Kinetic evidence for formation of an aquacobalamin intermediate
Walker, David T.,Dassanayake, Rohan S.,Garcia, Kamille A.,Mukherjee, Riya,Brasch, Nicola E.
, p. 3049 - 3053 (2013)
The essential but also toxic gaseous signaling molecule nitric oxide is scavenged by the reduced vitamin B12 complex cob(II)alamin. The resulting complex, nitroxylcobalamin [NO--Cbl(III)], is rapidly oxidized to nitrocobalamin (NO2Cbl) in the presence of oxygen; however, it is unlikely that nitrocobalamin is itself stable in biological systems. Kinetic studies on the reaction between NO2Cbl and the important intracellular antioxidant, glutathione (GSH), are reported. In this study, a reaction pathway is proposed in which the β-axial ligand of NO2Cbl is first substituted by water to give aquacobalamin (H 2OCbl+), which then reacts further with GSH to form glutathionylcobalamin (GSCbl). Independent measurements of the four associated rate constants k1, k-1, k2, and k-2 support the proposed mechanism. These findings provide insight into the fundamental mechanism of ligand substitution reactions of cob(III)alamins with inorganic ligands at the β-axial site. Kinetic studies on the reaction of nitrocobalamin (NO2Cbl) with glutathione show that glutathionylcobalamin (GSCbl) is formed via an aquacobalamin (H 2OCbl+) intermediate. This reaction pathway is demonstrated by independently determining individual rate constants for each step.
