60-89-9

Basic information

• Product Name: pecazine
• Synonyms: pecazine;Pacazine;MEPAZINE;10-[(1-Methyl-3-piperidinyl)methyl]-10H-phenothiazine;Nothiazine;Paxital;Pecatal;(N-Methyl-3-piperidyl)methylphenothiazine
• CAS NO: 60-89-9
• Molecular Formula: C₁₉H₂₂N₂S
• Molecular Weight: 310.463
• EINECS: 200-490-8
• Mol File: 60-89-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 80°C
• Boiling Point: bp4 230-235°
• Flash Point: 222.6°C
• Appearance: /
• Density: 1.1252 (rough estimate)
• Vapor Pressure: 4.29E-08mmHg at 25°C
• Refractive Index: 1.6270 (estimate)
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Water Solubility: 5.588mg/L(24 oC)
• CAS DataBase Reference: pecazine(CAS DataBase Reference)
• NIST Chemistry Reference: pecazine(60-89-9)
• EPA Substance Registry System: pecazine(60-89-9)

Safety Data

• Hazardous Substances Data: 60-89-9(Hazardous Substances Data)

Usage

Uses

Pecazine Hydrochloride acts as an anti-HIV agent in the form of C-C chemokine inhibitors.

Therapeutic Function

Tranquilizer

InChI:InChI=1/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3

Upstream product

• 92-84-2 10H-phenothiazine 
• 52694-50-5 3-(chloromethyl)-1-methylpiperidine 

Relevant articles and documents

Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors

Analogs of the psychotropic phenothiazines were synthesized and examined as antitubercular agents against Mycobacterium tuberculosis H37Rv. The compounds were subsequently counter-screened for binding to the dopaminergic-receptor subtypes D1, D2, D3 and the serotonergic-receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2C. The most active compounds showed MICs from 2 to 4 μg/mL and had overall reduced binding to the dopamine and serotonin receptors compared to chlorpromazine and trifluoperazine.