60-99-1

Basic information

• Product Name: (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
• Synonyms: (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine;(-)-3-(2-Methoxyphenothiazin-10-yl)-2-methylpropyldimethylamine;(-)-phenothiazin;10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (-)-;10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (R)-;2-Methoxytrimeprazine;3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine;7044 R.P.
• CAS NO: 60-99-1
• Molecular Formula: C₁₉H₂₄N₂OS
• Molecular Weight: 444.54
• EINECS: 200-495-5
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 60-99-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 117°C
• Boiling Point: 468 °C at 760 mmHg
• Flash Point: 236.8 °C
• Appearance: /
• Density: 1.0897 (rough estimate)
• Vapor Pressure: 6.22E-09mmHg at 25°C
• Refractive Index: 1.5950 (estimate)
• Water Solubility: 20mg/L(25 oC)
• CAS DataBase Reference: (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT(60-99-1)
• EPA Substance Registry System: (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT(60-99-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• RIDADR: 3249
• RTECS: SO6125000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 60-99-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 60-99-1 differently. You can refer to the following data:
1. Analgesic
2. (R)-Methotrimeprazine acts as an analgesic agent.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.

Brand name

Levoprome (Immunex).

Therapeutic Function

Analgesic

InChI:InChI=1/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-11-15(22-4)9-10-17(19)21/h5-11,14H,12-13H2,1-4H3

Synthetic route

Methotrimeprazine (851-68-3) → levomepromazine (60-99-1)

Conditions	Yield
With D-tartaric acid

(S)-γ-(2-methoxy-phenothiazin-10-yl)-isobutylamin; hydrochloride (98284-19-6) + aqueous methanol. formaldehyde → levomepromazine (60-99-1)

Conditions	Yield
anschliessende Hydrierung an Platin;

Upstream product

• 851-68-3 Methotrimeprazine 
• 98284-19-6 (S)-γ-(2-methoxy-phenothiazin-10-yl)-isobutylamin; hydrochloride