6004-53-1

Basic information

• Product Name: 1-CYCLOHEXYL-2-HYDROXYETHANONE
• Synonyms: 1-CYCLOHEXYL-2-HYDROXYETHANONE
• CAS NO: 6004-53-1
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.2
• Mol File: 6004-53-1.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-CYCLOHEXYL-2-HYDROXYETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOHEXYL-2-HYDROXYETHANONE(6004-53-1)
• EPA Substance Registry System: 1-CYCLOHEXYL-2-HYDROXYETHANONE(6004-53-1)

Safety Data

• Hazardous Substances Data: 6004-53-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 22, p. 607, 1981 DOI: 10.1016/S0040-4039(01)92501-8

Upstream product

• 37166-70-4 acetic acid 2-cyclohexyl-2-oxoethyl ester 
• 31151-40-3 2-cyclohexyl-1-diazo-2-ethanone 
• 56077-28-2 Bromomethyl cyclohexyl ketone 
• 124-41-4 sodium methylate 
• 917-64-6 methyl magnesium iodide 
• 107-16-4 glycolonitrile 
• 931-51-1 cyclohexylmagnesiumchloride 
• 60-29-7 diethyl ether 
• 71-43-2 benzene 
• 13676-37-4 2-Ethoxy-2-cyclohexyliden-ethanol 
• 103649-10-1 2-ethylsulfanyl-2-cyclohexyliden-ethanol 
• 69097-20-7 tris(trimethylsilyloxy)ethylene 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 1892-09-7 2-chloro-1-cyclohexyl-1-ethanone 

Downstream Products

• 95486-62-7 cyclohexyl-glyoxal-bis-(2,4-dinitro-phenylhydrazone) 
• 61414-09-3 1-cyclohexylethane-1,2-diol 
• 177973-73-8 benzoic acid 2-cyclohexyl-2-oxoethyl ester 
• 61883-66-7 butyl-(4-cyclohexyl-oxazol-2-yl)-amine 
• 80520-90-7 2-cyclohexyl-2-oxoethyl benzenesulfonate 
• 98-89-5 Cyclohexanecarboxylic acid 
• 170451-00-0 1-(Methoxymethoxy)methyl cyclohexyl ketone 
• 4354-49-8 2-cyclohexyl-2-oxoethanoic acid 
• 244031-74-1 1-cyclohexyl-2-(tetrahydro-pyran-2-yloxy)-ethanone 
• 73434-38-5 methyl (E)-4-cyclohexyl-4-oxobut-2-enoate 
• 40115-00-2 2-cyclohexyl-quinoxaline 
• 53190-45-7 2-cyclohexylpyrazine 

Relevant articles and documents

Palladium-Catalyzed (3+3) Annulation of Allenylethylene Carbonates with Nitrile Oxides

In this paper, we designed and synthesized a new type of cyclic carbonates, allenylethylene carbonates (AECs). With AECs as reactive precursors, we developed palladium-catalyzed (3+3) annulation of AECs with nitrile oxides. Various AECs worked well in this reaction under mild reaction conditions. A variety of 5,6-dihydro-1,4,2-dioxazine derivatives with allenyl quaternary stereocenters can be accessed in a facile manner in high yields (≤98%).

Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes

A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.

Vinylethylene Carbonates as α,β-Unsaturated Aldehyde Surrogates for Regioselective [3 + 3] Cycloaddition

Herein, we report a novel stepwise addition-controlled ring size method, to access tetrahydropyrimidines through an operationally simple [3 + 3] cycloaddition of vinylethylene carbonates with triazinanes. Interestingly, we could also use this method for a [3 + 3] oxidative cycloaddition, which allows the facile synthesis of polysubstituted terphenyls under mild conditions. Mechanistic studies suggest that vinylethylene carbonates could generate α,β-unsaturated aldehydes as 3-carbon synthons for cycloaddition via a combination process of Pd-catalyzed decarboxylation and β-H elimination.