6004-59-7

Basic information

• Product Name: cyclooctyl(phenyl)methanone
• Synonyms: cyclooctyl(phenyl)methanone
• CAS NO: 6004-59-7
• Molecular Weight: 216.323
• Mol File: 6004-59-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: cyclooctyl(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: cyclooctyl(phenyl)methanone(6004-59-7)
• EPA Substance Registry System: cyclooctyl(phenyl)methanone(6004-59-7)

Safety Data

• Hazardous Substances Data: 6004-59-7(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 292-64-8 Cyclooctan 
• 100-52-7 benzaldehyde 
• 69126-54-1 benzyl cyclooctyl ether 
• 50361-50-7 1-((trimethylsilyl)oxy)cyclooctanecarbonitrile 
• 502-49-8 cycloactanone 
• 172230-04-5 1-benzoylcyclooctanol 
• 931-88-4 cis-Cyclooctene 
• 82700-57-0 cyclooctyl(phenyl)methanol 

Downstream Products

• 515154-98-0 C₂₅H₃₅NO₂ 
• 515154-97-9 C₂₅H₃₅NO₂ 

Relevant articles and documents

Synergistic Activation of Amides and Hydrocarbons for Direct C(sp3)–H Acylation Enabled by Metallaphotoredox Catalysis

The utilizations of omnipresent, thermodynamically stable amides and aliphatic C(sp3)?H bonds for various functionalizations are ongoing challenges in catalysis. In particular, the direct coupling between the two functional groups has not been realized. Here, we report the synergistic activation of the two challenging bonds, the amide C?N and unactivated aliphatic C(sp3)?H, via metallaphotoredox catalysis to directly acylate aliphatic C?H bonds utilizing amides as stable and readily accessible acyl surrogates. N-acylsuccinimides served as efficient acyl reagents for the streamlined synthesis of synthetically useful ketones from simple C(sp3)?H substrates. Detailed mechanistic investigations using both computational and experimental mechanistic studies were performed to construct a detailed and complete catalytic cycle. The origin of the superior reactivity of the N-acylsuccinimides over other more reactive acyl sources such as acyl chlorides was found to be an uncommon reaction pathway which commences with C?H activation prior to oxidative addition of the acyl substrate.

A ketone the synthetic method of the compound of (by machine translation)

The invention discloses a method for the synthesis of ketone compound, the aldehyde compound and cyclanes mixed or dissolved in organic solvent, in the microwave radiation and presence of radical initiator under the condition of the 140 [...] 180 °C reaction to obtain the target product ketone compound, in the synthesis method of the reaction equation: , Wherein R 1 is phenyl or substituted phenyl, substituted phenyl benzene ring substituted the base is the fluorine, chloro, bromo, methyl, methoxy, trifluoromethyl or hydroxy in one or more of, the position of the substituent on the benzene ring is ortho, meta or para position, as n the 1 [...] 4 integer between the, free-radical initiator is benzoyl peroxide, di-tert-butyl peroxide, or cumyl peroxide, organic solvent as the alkane or benzene. The invention discloses method for the synthesis of the raw material is cheap and easy to obtain, good atom economy, wide range of the application of substrates, and the like, is suitable for industrial production. (by machine translation)

Conversion of ketone trimethylsilylcyanohydrins to several types of compounds

Cyclic ketone O-trimethylsilylcyanohydrins (2) were prepared and converted to various compounds: α-hydroxyketones (3), dehydroxylated ketones (4), α,β-unsaturated ketones (9), tricyclic ketones (10), 1-ethoxycarbonyl-4- phenyl-1,2,4a,5,6,7,8,8a-octahydro-2-naphthalenone (13), 1- phenylperhydroisocoumarin (18) and 1,2,3,4,4a,10,11,11a-octahydro-5h- benzo[a,d]cyclohepten-10-one (20).