60045-61-6

Basic information

• Product Name: 5-ANISYLIDENE-2-THIOBARBITURIC ACID
• Synonyms: (5E)-6-Hydroxy-5-(4-methoxybenzylidene)-2-sulfanylpyrimidin-4(5H)-one; 2(5H)-pyrimidinethione, 4,6-dihydroxy-5-[(4-methoxyphenyl)methylene]-; 4(5H)-pyrimidinone, 6-hydroxy-2-mercapto-5-[(4-methoxyphenyl)methylene]-, (5E)-; 4,6(1H,5H)-Pyrimidinedione, dihydro-5-[(4-methoxyphenyl)methylene]-2-thioxo-; 5-(4-Methoxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-(4-methoxybenzylidene)-2-thioxohexahydropyrimidine-4,6-dione
• CAS NO: 60045-61-6
• Molecular Formula: C₁₂H₁₀N₂O₃S
• Molecular Weight: 262.2891
• Mol File: 60045-61-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 467.2°C at 760 mmHg
• Flash Point: 236.4°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 1.57E-09mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 5-ANISYLIDENE-2-THIOBARBITURIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ANISYLIDENE-2-THIOBARBITURIC ACID(60045-61-6)
• EPA Substance Registry System: 5-ANISYLIDENE-2-THIOBARBITURIC ACID(60045-61-6)

Safety Data

• Hazardous Substances Data: 60045-61-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H10N2O3S/c1-17-8-4-2-7(3-5-8)6-9-10(15)13-12(18)14-11(9)16/h2-6H,1H3,(H2,13,14,15,16,18)

Upstream product

• 504-17-6 4,6-dihydroxy-2-mercaptopyrimidine 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1240506-96-0 (5Z)-2-(benzylthio)-5-(4-methoxybenzylidene)pyrimidine-4,6(1H,5H)-dione 

Relevant articles and documents

Verjuice as a green and bio-degradable solvent/catalyst for facile and eco-friendly synthesis of 5-arylmethylenepyrimidine-2,4,6-trione, pyrano[2,3-d]pyrimidinone and pyrimido[4,5-d]pyrimidinone derivatives

Verjuice (unripe grape juice), a natural mixture of organic acids, which is identified by pH-metric and TGA analysis, is efficiently used for the promotion of the synthesis of 5-arylmethylenepyrimidine-2,4,6-triones, via Knovenagel condensation reaction between barbituric or thiobarbituric acid and aldehydes. Verjuice is also employed for the effective synthesis of pyrano[2,3-d]pyrimidinone derivatives via a three-component reaction of barbituric acid or its thio analogue, aldehydes and malononitrile. In the same way, pyrimido[4,5-d]pyrimidinone derivatives are simply produced via the reaction of barbituric acid, aldehydes and urea or thiourea in the presence of verjuice. This green methodology rewards notable advantages including simple procedures, acceptable reaction times, easy work-up, high yields, circumventing the use of any expensive starting materials, volatile and hazardous organic solvents during the reaction and work-up process, and use of a natural, low-cost, reusable, and bio-degradable catalyst.

Sulfamic Acid Catalyzed Atom Economic, Eco-friendly Synthesis of Novel 7-(Aryl)-10-thioxo-7,9,10,11-tetrahedro-6H-pyrimido-[5′4′:5,6]pyrano[3,2-c]quinoline-6,8(5H)-dione and its Derivatives

A series of novel 7-(3-chloro-phenyl)-10-thioxo-7,9,10,11-tetrahedro-6H-pyrimido-[5′4′:5,6] pyrano[3,2-c]quinoline-6,8(5H)-dione derivatives have been synthesized through the multi-component condensation of aromatic aldehydes, barbituric acid, and 2,4-dih

New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof

PURPOSE: A novel compound with skin whitening, antioxidation, and PPAR activation effects, and a medical use thereof are provided to be used for a pharmaceutical composition or a cosmetic product. CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound as an active ingredient. An antioxidative composition for preventing or treating oxidative diseases contains the compound of chemical formula 1 as an active ingredient. The oxidative diseases are selected among skin aging, pigmentation, wrinkling, psoriasis, or eczema. The composition prevents or treats diseases which are regulated by PPAR(peroxisome proliferator-activated receptor) activity. The PPAR includes PPAR alpha or PPAR gamma.