6007-71-2

Basic information

• Product Name: 2-methyl-2,5-dihydrothiophene 1,1-dioxide
• Synonyms: 2,5-Dihydro-2-methyl-thiophene 1,1-dioxide; 2-Methyl-2,5-dihydrothiophene 1,1-dioxide; thiophene, 2,5-dihydro-2-methyl-, 1,1-dioxide
• CAS NO: 6007-71-2
• Molecular Formula: C₅H₈O₂S
• Molecular Weight: 132.1808
• Mol File: 6007-71-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 284.9°C at 760 mmHg
• Flash Point: 163.6°C
• Density: 1.217g/cm³
• Vapor Pressure: 0.00499mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 2-methyl-2,5-dihydrothiophene 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2,5-dihydrothiophene 1,1-dioxide(6007-71-2)
• EPA Substance Registry System: 2-methyl-2,5-dihydrothiophene 1,1-dioxide(6007-71-2)

Safety Data

• Hazardous Substances Data: 6007-71-2(Hazardous Substances Data)

Usage

General Description

2-methyl-2,5-dihydrothiophene 1,1-dioxide is a chemical compound with a molecular formula of C5H8O2S. It is a colorless liquid with a molecular weight of 132.18 g/mol. It is commonly used as a solvent, in the manufacturing of pharmaceuticals, and as a building block in the production of other chemicals. 2-methyl-2,5-dihydrothiophene 1,1-dioxide is also used in the synthesis of various organic compounds, and it has applications in the field of organic chemistry and material science. Additionally, it is flammable and should be handled with care and stored in a well-ventilated area.

Upstream product

• 2004-70-8 1-methylbuta-1,3-diene 
• 77-79-2 3-Sulfolene 
• 74-88-4 methyl iodide 
• 106212-24-2 (+/-)-2,5-dihydro-2-(trimethylsilyl)thiophene 1,1-dioxide 
• 53336-42-8 3-bromo-2,3-dihydro-thiophene-1,1-dioxide 
• 61464-28-6 2-methyl-4,5-dihydrothiophene 1,1-dioxide 

Downstream Products

• 30293-90-4 4-methyl-3a,4,6,6a-tetrahydro-3H-thieno[3,4-c]pyrazole 5,5-dioxide 
• 30293-89-1 6-methyl-3a,4,6,6a-tetrahydro-3H-thieno[3,4-c]pyrazole 5,5-dioxide 
• 54795-49-2 (+/-)-3c-methyl-cyclohex-4-ene-1r,2c-dicarboxylic acid dimethyl ester 
• 106212-25-3 2-methyl-5-(trimethylsilyl)-3-sulfolene 
• 61464-28-6 2-methyl-4,5-dihydrothiophene 1,1-dioxide 
• 109-68-2 2-pentene 
• 375-81-5 perfluoro-n-pentane sulfonylfluoride 
• 28084-22-2 perfluoromethylbutane sulfonylfluoride 

Relevant articles and documents

A Study of 2-Methyl-3-phenylsulphinyl-2,3,4,5-tetrahydrothiophene 1,1-Dioxides: NMR Spectra, Crystal Structure and Dehydrosulphinylations

The (2R*,3S*,SR*) and (2R*,3S*,SS*) isomers of 2-methyl-3-phenylsulphinyl-2,3,4,5-tetrahydrothiophene 1,1-dioxide were converted to 2-methyl-4,5-dihydrothiophene 1,1-dioxide in refluxing toluene, while the (2S*,3S*,SR*) isomer underwent thermolysis to give 2-methyl-2,5-dihydrothiophene 1,1-dioxide.No reaction of the (2S*,3S*,SS*) isomer occurred because the required conformation in dehydrosulphinylation was prohibited by the steric effect of the methyl and phenyl groups.

4-Bromo-2-sulfolenes. Butadienyl Cation Equivalents

4-Bromo-2-sulfolene and 4-bromo-3-methyl-2-sulfolene react with alkylcuprates to give direct substitution products, with vinyl- or phenylcuprates or sulfur-containing nucleophiles to give allylic substitution products, and with strongly basic nucleophiles to give elimination products.The allylic substitution products and the isomerized direct substitution products are precursors for substituted 1,3-butadienes.Thus, these 4-bromo-2-sulfolenes serve as butadienyl cation equivalents.

One-Pot Sequential Acylation/Alkylation Reactions of 3-Sulfolenes

3-Sulfolene 2-anion and 3-methyl-3-sulfolene 2-anion have been generated at -105 deg C and are stable in the absence of electrophiles for at least 15 min at this temperature.These anions were used in sequential reactions with acyl chlorides and alkyl halides to yield the corresponding 2-acyl-2-alkyl-3-sulfolenes.